tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jan 24.
doi: 10.1002/jmv.27615. Online ahead of print.
Role of Genetic Variants and Host Polymorphisms on COVID-19: From Viral Entrance Mechanisms to Immunological Reactions
Abolfazl Adli[SUP] 1 [/SUP], Mandana Rahimi[SUP] 2 [/SUP], Reza Khodaie[SUP] 3 [/SUP], Niloofar Hashemzaei[SUP] 4 [/SUP], Sayed Mostafa Hosseini[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by a highly pathogenic emerging virus, is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our knowledge regarding the pathogenesis of this virus is in infancy; however, the investigation on the pathogenic mechanisms of the SARS-CoV-2 is underway. In the COVID-19, one of the most remarkable characteristics is the wide range of diseases manifestation and severity seen across individuals of different ethnic backgrounds and geographical locations. In order to effectively manage COVID-19 in the populations, beyond SARS-CoV-2 detection, serological response assessment, and analytic techniques, it is critical to obtain knowledge about at-risk individuals and comprehend the identified variations in the disease's severity in general and also in the populations' levels. Several factors can contribute to variation in disease presentation, including population density, gender and age differences, and comorbid circumstances including diabetes mellitus, hypertension, and obesity. Genetic factors presumably influence SARS-CoV-2 infection susceptibility. Besides, COVID-19 has also been linked with a higher risk of mortality in men and certain ethnic groups, revealing that host genetic characteristics may affect the individual risk of death. Also, genetic variants involved in pathologic processes, including virus entrance into cells, antiviral immunity, and inflammatory response, are not entirely understood. Regarding SARS-CoV-2 infection characteristics, the present review suggests that various genetic polymorphisms influence virus pathogenicity and host immunity, which might have significant implications for understanding and interpreting the matter of genetics in SARS-CoV-2 pathogenicity and customized integrative medical care based on the population investigation. This article is protected by copyright. All rights reserved.
Keywords: ACE2; COVID-19; Genetic diversity; Polymorphism; SARS-CoV-2; TMPRSS2.
. 2022 Jan 24.
doi: 10.1002/jmv.27615. Online ahead of print.
Role of Genetic Variants and Host Polymorphisms on COVID-19: From Viral Entrance Mechanisms to Immunological Reactions
Abolfazl Adli[SUP] 1 [/SUP], Mandana Rahimi[SUP] 2 [/SUP], Reza Khodaie[SUP] 3 [/SUP], Niloofar Hashemzaei[SUP] 4 [/SUP], Sayed Mostafa Hosseini[SUP] 1 [/SUP]
Affiliations
- PMID: 35076118
- DOI: 10.1002/jmv.27615
Abstract
Coronavirus disease 2019 (COVID-19), caused by a highly pathogenic emerging virus, is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our knowledge regarding the pathogenesis of this virus is in infancy; however, the investigation on the pathogenic mechanisms of the SARS-CoV-2 is underway. In the COVID-19, one of the most remarkable characteristics is the wide range of diseases manifestation and severity seen across individuals of different ethnic backgrounds and geographical locations. In order to effectively manage COVID-19 in the populations, beyond SARS-CoV-2 detection, serological response assessment, and analytic techniques, it is critical to obtain knowledge about at-risk individuals and comprehend the identified variations in the disease's severity in general and also in the populations' levels. Several factors can contribute to variation in disease presentation, including population density, gender and age differences, and comorbid circumstances including diabetes mellitus, hypertension, and obesity. Genetic factors presumably influence SARS-CoV-2 infection susceptibility. Besides, COVID-19 has also been linked with a higher risk of mortality in men and certain ethnic groups, revealing that host genetic characteristics may affect the individual risk of death. Also, genetic variants involved in pathologic processes, including virus entrance into cells, antiviral immunity, and inflammatory response, are not entirely understood. Regarding SARS-CoV-2 infection characteristics, the present review suggests that various genetic polymorphisms influence virus pathogenicity and host immunity, which might have significant implications for understanding and interpreting the matter of genetics in SARS-CoV-2 pathogenicity and customized integrative medical care based on the population investigation. This article is protected by copyright. All rights reserved.
Keywords: ACE2; COVID-19; Genetic diversity; Polymorphism; SARS-CoV-2; TMPRSS2.