tetano
Editor, Senior Moderator
J Med Virol
. 2020 Jul 29.
doi: 10.1002/jmv.26367. Online ahead of print.
Risk factors for the COVID-19 severity and its correlation with viral shedding: a retrospective cohort study
Xinchun Zheng[SUP] 1 [/SUP], Jiehua Chen[SUP] 1 [/SUP], Lisi Deng[SUP] 1 [/SUP], Zhaoxiong Fang[SUP] 2 [/SUP], Gongqi Chen[SUP] 1 [/SUP], Di Ye[SUP] 1 [/SUP], Jinyu Xia[SUP] 1 [/SUP], Zhongsi Hong[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) have become a pandemic in the world. This study is aim to explore risk factors for COVID-19 severity in the early stage and the correlation between the viral shedding and COVID-19 severity.
Methods: We included inpatient with laboratory confirmed COVID-19 who had been discharged by Mar 9, 2020.The medical record data and dynamic change of biochemical indicators in-hospital were compared between common and severe patients.
Results: 80 patients were included in this study. Multivariable regression demonstrated increasing odds of severity associated with the duration of fever (odds ratio 1.42, 95% CI 1.10-1.82, per day increase; p=0?007), CRP (1.26, 95% CI 1.04-1.52; p=0.02), and PO[SUB]2[/SUB] <80 mmHg (28.07, 95% CI 1.50-524.12; p=0.026) on admission. We found SARS-CoV-2 viral RNA could be long-term presence in respiratory tract and fecal sample, up to 43 and 46 days respectively. However, the duration of viral shedding have no correlation with the COVID-19 severity.
Conclusion: The duration of fever, elevated CRP and PO[SUB]2[/SUB] < 80 mmHg on admission were associated with the COVID-19 severity in the early stage and there is no correlation between the viral shedding and COVID-19 severity. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Retrospective cohort study; Risk factors; Severity; Viral shedding.
. 2020 Jul 29.
doi: 10.1002/jmv.26367. Online ahead of print.
Risk factors for the COVID-19 severity and its correlation with viral shedding: a retrospective cohort study
Xinchun Zheng[SUP] 1 [/SUP], Jiehua Chen[SUP] 1 [/SUP], Lisi Deng[SUP] 1 [/SUP], Zhaoxiong Fang[SUP] 2 [/SUP], Gongqi Chen[SUP] 1 [/SUP], Di Ye[SUP] 1 [/SUP], Jinyu Xia[SUP] 1 [/SUP], Zhongsi Hong[SUP] 1 [/SUP]
Affiliations
- PMID: 32725915
- DOI: 10.1002/jmv.26367
Abstract
Background: Coronavirus disease 2019 (COVID-19) have become a pandemic in the world. This study is aim to explore risk factors for COVID-19 severity in the early stage and the correlation between the viral shedding and COVID-19 severity.
Methods: We included inpatient with laboratory confirmed COVID-19 who had been discharged by Mar 9, 2020.The medical record data and dynamic change of biochemical indicators in-hospital were compared between common and severe patients.
Results: 80 patients were included in this study. Multivariable regression demonstrated increasing odds of severity associated with the duration of fever (odds ratio 1.42, 95% CI 1.10-1.82, per day increase; p=0?007), CRP (1.26, 95% CI 1.04-1.52; p=0.02), and PO[SUB]2[/SUB] <80 mmHg (28.07, 95% CI 1.50-524.12; p=0.026) on admission. We found SARS-CoV-2 viral RNA could be long-term presence in respiratory tract and fecal sample, up to 43 and 46 days respectively. However, the duration of viral shedding have no correlation with the COVID-19 severity.
Conclusion: The duration of fever, elevated CRP and PO[SUB]2[/SUB] < 80 mmHg on admission were associated with the COVID-19 severity in the early stage and there is no correlation between the viral shedding and COVID-19 severity. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Retrospective cohort study; Risk factors; Severity; Viral shedding.