tetano
Editor, Senior Moderator
J Med Virol
. 2021 Jun 26.
doi: 10.1002/jmv.27162. Online ahead of print.
Retrospective SARS-CoV-2 IgG screening during the first wave (March-June 2020) of the COVID-19 pandemic in the UK
Paul William Bird[SUP] 1 [/SUP], Kyran Sandhu[SUP] 1 [/SUP], Oliver Fletcher[SUP] 1 [/SUP], Billy Ames[SUP] 1 [/SUP], Oliver Toovey[SUP] 2 [/SUP], Julian Wei-Tze Tang[SUP] 3 [/SUP]
Affiliations
Abstract
During the "first wave" of COVID-19 pandemic in the UK (March to June 2020), the city of Leicester was particularly hard hit resulting in re-imposed lockdown measures. Although initial PCR testing for SARS-CoV-2 was attempted within the community, testing was soon abandoned due to an inability to keep up with demand by local laboratories. It is therefore feasible that undiagnosed transmission of COVID-19 in the community by asymptomatic individuals was a real possibility. Therefore, retrospective SARS-CoV-2 IgG testing of archived sera from out-patients visiting University Hospitals of Leicester NHS Trust service was performed to investigate the transmission of SARS-CoV-2 in the community. A total of 1779 sea samples were tested from samples collected between 16[SUP]th[/SUP] March and 3[SUP]rd[/SUP] June 2020, of which 202 (11.35%) were SARS-CoV-2 IgG positive. Positivity was lowest in March (2.54%) at the beginning of the pandemic before peaking in April (17.16%) before decline in May and June (11.16% and 12.68% respectively). This retrospective screening offers some insight into the early patterns of SARS-CoV-2 transmission within a sampled community population during the first wave of the COVID-19 pandemic. Supporting the argument for more community screening during high incidences of pandemics. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus < Virus classification; Immune globulin < Antiviral agents; SARS coronavirus < Virus classification.
. 2021 Jun 26.
doi: 10.1002/jmv.27162. Online ahead of print.
Retrospective SARS-CoV-2 IgG screening during the first wave (March-June 2020) of the COVID-19 pandemic in the UK
Paul William Bird[SUP] 1 [/SUP], Kyran Sandhu[SUP] 1 [/SUP], Oliver Fletcher[SUP] 1 [/SUP], Billy Ames[SUP] 1 [/SUP], Oliver Toovey[SUP] 2 [/SUP], Julian Wei-Tze Tang[SUP] 3 [/SUP]
Affiliations
- PMID: 34173993
- DOI: 10.1002/jmv.27162
Abstract
During the "first wave" of COVID-19 pandemic in the UK (March to June 2020), the city of Leicester was particularly hard hit resulting in re-imposed lockdown measures. Although initial PCR testing for SARS-CoV-2 was attempted within the community, testing was soon abandoned due to an inability to keep up with demand by local laboratories. It is therefore feasible that undiagnosed transmission of COVID-19 in the community by asymptomatic individuals was a real possibility. Therefore, retrospective SARS-CoV-2 IgG testing of archived sera from out-patients visiting University Hospitals of Leicester NHS Trust service was performed to investigate the transmission of SARS-CoV-2 in the community. A total of 1779 sea samples were tested from samples collected between 16[SUP]th[/SUP] March and 3[SUP]rd[/SUP] June 2020, of which 202 (11.35%) were SARS-CoV-2 IgG positive. Positivity was lowest in March (2.54%) at the beginning of the pandemic before peaking in April (17.16%) before decline in May and June (11.16% and 12.68% respectively). This retrospective screening offers some insight into the early patterns of SARS-CoV-2 transmission within a sampled community population during the first wave of the COVID-19 pandemic. Supporting the argument for more community screening during high incidences of pandemics. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus < Virus classification; Immune globulin < Antiviral agents; SARS coronavirus < Virus classification.