tetano
Editor, Senior Moderator
J Med Virol
. 2020 Oct 28.
doi: 10.1002/jmv.26637. Online ahead of print.
Reinfection of COVID-19 after 3 months with a distinct and more aggressive clinical presentation: case report
Danielle de Araujo Torres[SUP] 1 [/SUP], Luciana do Carmo Bueno Ribeiro[SUP] 2 [/SUP], Anna Patr?cia de Freitas Linhares Riello[SUP] 3 [/SUP], Dafne Dain Gandelman Horovitz[SUP] 4 [/SUP], Luis Felipe Ribeiro Pinto[SUP] 5 [/SUP], Julio Croda[SUP] 6 [/SUP]
Affiliations
Abstract
The sudden pandemic caused by SARS-CoV-2 exposed healthcare professionals worldwide to high viral loads, in an early epidemiological moment, often without the recommended personal protective equipment. We report the case of a Brazilian doctor who, after presenting a mild clinical episode of COVID-19 with molecular confirmation by RT-PCR in March 2020, appeared with a new acute infection by SARS-CoV-2 three months later. In middle of June, she had significant and very specific symptoms of COVID-19 with tomographic and serological confirmation of reinfection. There is a strong probability that these two episodes of infection were caused by different viral strains and that each genetic variation is related to specific clinical manifestations. We observed that, in addition to the different symptoms presented in the reinfections' episode, there was a more intense organic inflammatory response to the virus, with clinical repercussion. This clinical case should be an alert regarding the maintenance of individual protection among health cares, even in individuals who have already had COVID-19, since there is still no guarantee of prolonged immunity. This article is protected by copyright. All rights reserved.
Keywords: Humoral immunity < Immune responses; Immunity/Immunization < Epidemiology; Inflammation < Immune responses; Public policy < Social Science; Reinfection < Immune responses; SARS coronavirus < Virus classification.
. 2020 Oct 28.
doi: 10.1002/jmv.26637. Online ahead of print.
Reinfection of COVID-19 after 3 months with a distinct and more aggressive clinical presentation: case report
Danielle de Araujo Torres[SUP] 1 [/SUP], Luciana do Carmo Bueno Ribeiro[SUP] 2 [/SUP], Anna Patr?cia de Freitas Linhares Riello[SUP] 3 [/SUP], Dafne Dain Gandelman Horovitz[SUP] 4 [/SUP], Luis Felipe Ribeiro Pinto[SUP] 5 [/SUP], Julio Croda[SUP] 6 [/SUP]
Affiliations
- PMID: 33112002
- DOI: 10.1002/jmv.26637
Abstract
The sudden pandemic caused by SARS-CoV-2 exposed healthcare professionals worldwide to high viral loads, in an early epidemiological moment, often without the recommended personal protective equipment. We report the case of a Brazilian doctor who, after presenting a mild clinical episode of COVID-19 with molecular confirmation by RT-PCR in March 2020, appeared with a new acute infection by SARS-CoV-2 three months later. In middle of June, she had significant and very specific symptoms of COVID-19 with tomographic and serological confirmation of reinfection. There is a strong probability that these two episodes of infection were caused by different viral strains and that each genetic variation is related to specific clinical manifestations. We observed that, in addition to the different symptoms presented in the reinfections' episode, there was a more intense organic inflammatory response to the virus, with clinical repercussion. This clinical case should be an alert regarding the maintenance of individual protection among health cares, even in individuals who have already had COVID-19, since there is still no guarantee of prolonged immunity. This article is protected by copyright. All rights reserved.
Keywords: Humoral immunity < Immune responses; Immunity/Immunization < Epidemiology; Inflammation < Immune responses; Public policy < Social Science; Reinfection < Immune responses; SARS coronavirus < Virus classification.