tetano
Editor, Senior Moderator
J Med Virol
. 2021 Dec 15.
doi: 10.1002/jmv.27525. Online ahead of print.
Rare case of drug-induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID-19
Ping Jiang[SUP] 1 [/SUP], Shuang-Hua Wu[SUP] 2 [/SUP], Ting Zhu[SUP] 3 [/SUP], Yuan Guo[SUP] 1 [/SUP], Yi He[SUP] 1 [/SUP]
Affiliations
Abstract
Methylprednisolone (MP) is usually used to reduce the inflammation reaction and tissue damage, which may have a benefit assistant treatment effect on coronavirus disease 2019 (COVID-19). However, We present the case of a child who manifest significant bradycardia with the use of just low dose MP on the premise of the long-term use of arbidol. Arbidol can affect the activity of CYP3A4 which is also a key metabolic enzyme of MP by competitive inhibition, which is easy to aggravate the side effects of the MP. Therefore, more attention should be paid with bradycardia occurrence in the patient with COVID-19 when MP is considered in COVID-19. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus; Infection; Inflammation.
. 2021 Dec 15.
doi: 10.1002/jmv.27525. Online ahead of print.
Rare case of drug-induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID-19
Ping Jiang[SUP] 1 [/SUP], Shuang-Hua Wu[SUP] 2 [/SUP], Ting Zhu[SUP] 3 [/SUP], Yuan Guo[SUP] 1 [/SUP], Yi He[SUP] 1 [/SUP]
Affiliations
- PMID: 34911144
- DOI: 10.1002/jmv.27525
Abstract
Methylprednisolone (MP) is usually used to reduce the inflammation reaction and tissue damage, which may have a benefit assistant treatment effect on coronavirus disease 2019 (COVID-19). However, We present the case of a child who manifest significant bradycardia with the use of just low dose MP on the premise of the long-term use of arbidol. Arbidol can affect the activity of CYP3A4 which is also a key metabolic enzyme of MP by competitive inhibition, which is easy to aggravate the side effects of the MP. Therefore, more attention should be paid with bradycardia occurrence in the patient with COVID-19 when MP is considered in COVID-19. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus; Infection; Inflammation.