tetano
Editor, Senior Moderator
J Med Virol
. 2024 Jul;96(7):e29819.
doi: 10.1002/jmv.29819. Protective role of macrophages from maternal-fetal interface in unvaccinated coronavirus disease 2019 pregnant women
Laetitia Gay[SUP] 1 [/SUP], Sandra Madariaga Zarza[SUP] 1 [/SUP], Perla Abou Atmeh[SUP] 1 [/SUP], Marie-Sarah Rouvière[SUP] 2 [/SUP], Jonatane Andrieu[SUP] 3 [/SUP], Manon Richaud[SUP] 2 [/SUP], Asma Boumaza[SUP] 1 [/SUP], Laura Miquel[SUP] 4 [/SUP], Aïssatou Bailo Diallo[SUP] 1 [/SUP], Yassina Bechah[SUP] 1 [/SUP], Myriem Otmani Idrissi[SUP] 1 [/SUP], Bernard La Scola[SUP] 1 [/SUP], Daniel Olive[SUP] 2 [/SUP], Noémie Resseguier[SUP] 5 [/SUP], Florence Bretelle[SUP] 1 4 [/SUP], Soraya Mezouar[SUP] 3 [/SUP], Jean-Louis Mege[SUP] 1 6 [/SUP]
Affiliations
Pregnant women represent a high-risk population for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. The presence of SARS-CoV-2 has been reported in placenta from infected pregnant women, but whether the virus influences placenta immune response remains unclear. We investigated the properties of maternal-fetal interface macrophages (MFMs) in a cohort of unvaccinated women who contracted coronavirus disease 2019 (COVID-19) during their pregnancy. We reported an infiltration of CD163[SUP]+[/SUP] macrophages in placenta from COVID-19 women 19 whereas lymphoid compartment was not affected. Isolated MFMs exhibited nonpolarized activated signature (NOS2, IDO1, IFNG, TNF, TGFB) mainly in women infected during the second trimester of pregnancy. COVID-19 during pregnancy primed MFM to produce type I and III interferon response to SARS-CoV-2 (Wuhan and δ strains), that were unable to elicit this in MFMs from healthy pregnant women. COVID-19 also primed SARS-CoV-2 internalization by MFM in an angiotensin-converting enzyme 2-dependent manner. Activation and recall responses of MFMs were influenced by fetal sex. Collectively, these findings support a role for MFMs in the local immune response to SARS-CoV-2 infection, provide a basis for protective placental immunity in COVID-19, and highlight the interest of vaccination in pregnant women.
Keywords: M1/M2 polarization; coronavirus disease 2019; fetal sex; maternal–fetal interface macrophages; pregnancy; type I and III interferons.
. 2024 Jul;96(7):e29819.
doi: 10.1002/jmv.29819. Protective role of macrophages from maternal-fetal interface in unvaccinated coronavirus disease 2019 pregnant women
Laetitia Gay[SUP] 1 [/SUP], Sandra Madariaga Zarza[SUP] 1 [/SUP], Perla Abou Atmeh[SUP] 1 [/SUP], Marie-Sarah Rouvière[SUP] 2 [/SUP], Jonatane Andrieu[SUP] 3 [/SUP], Manon Richaud[SUP] 2 [/SUP], Asma Boumaza[SUP] 1 [/SUP], Laura Miquel[SUP] 4 [/SUP], Aïssatou Bailo Diallo[SUP] 1 [/SUP], Yassina Bechah[SUP] 1 [/SUP], Myriem Otmani Idrissi[SUP] 1 [/SUP], Bernard La Scola[SUP] 1 [/SUP], Daniel Olive[SUP] 2 [/SUP], Noémie Resseguier[SUP] 5 [/SUP], Florence Bretelle[SUP] 1 4 [/SUP], Soraya Mezouar[SUP] 3 [/SUP], Jean-Louis Mege[SUP] 1 6 [/SUP]
Affiliations
- PMID: 39030992
- DOI: 10.1002/jmv.29819
Pregnant women represent a high-risk population for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. The presence of SARS-CoV-2 has been reported in placenta from infected pregnant women, but whether the virus influences placenta immune response remains unclear. We investigated the properties of maternal-fetal interface macrophages (MFMs) in a cohort of unvaccinated women who contracted coronavirus disease 2019 (COVID-19) during their pregnancy. We reported an infiltration of CD163[SUP]+[/SUP] macrophages in placenta from COVID-19 women 19 whereas lymphoid compartment was not affected. Isolated MFMs exhibited nonpolarized activated signature (NOS2, IDO1, IFNG, TNF, TGFB) mainly in women infected during the second trimester of pregnancy. COVID-19 during pregnancy primed MFM to produce type I and III interferon response to SARS-CoV-2 (Wuhan and δ strains), that were unable to elicit this in MFMs from healthy pregnant women. COVID-19 also primed SARS-CoV-2 internalization by MFM in an angiotensin-converting enzyme 2-dependent manner. Activation and recall responses of MFMs were influenced by fetal sex. Collectively, these findings support a role for MFMs in the local immune response to SARS-CoV-2 infection, provide a basis for protective placental immunity in COVID-19, and highlight the interest of vaccination in pregnant women.
Keywords: M1/M2 polarization; coronavirus disease 2019; fetal sex; maternal–fetal interface macrophages; pregnancy; type I and III interferons.