tetano
Editor, Senior Moderator
J Med Virol
. 2021 Apr 14.
doi: 10.1002/jmv.27021. Online ahead of print.
Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A Report of 2 Cases
Maria Cassia Mendes Correa[SUP] 1 2 [/SUP], Fabio E Leal[SUP] 3 4 [/SUP], Lucy S Villas Boas[SUP] 1 [/SUP], Steven S Witkin[SUP] 1 5 [/SUP], Anderson de Paula[SUP] 1 [/SUP], Tania Regina Tozetto Mendonza[SUP] 1 [/SUP], Noely Evangelista Ferreira[SUP] 1 [/SUP], Gislaine Curty[SUP] 4 [/SUP], Pedro Santos de Carvalho[SUP] 4 [/SUP], Lewis F Buss[SUP] 2 [/SUP], Silvia F Costa[SUP] 2 6 [/SUP], Flavia Mendes da Cunha Carvalho[SUP] 6 [/SUP], Joyce Kawakami[SUP] 7 [/SUP], Noemi Nosomi Taniwaki[SUP] 8 [/SUP], Heuder Paiao[SUP] 1 [/SUP], Joao Carlos da Silva Biz?rio[SUP] 3 [/SUP], Jaqueline Goes de Jesus[SUP] 2 6 [/SUP], Ester Cerdeira Sabino[SUP] 2 6 [/SUP], Camila Malta Romano[SUP] 1 [/SUP], Regina Maura Zetone Grepan[SUP] 3 [/SUP], Antonio Sesso[SUP] 6 [/SUP]
Affiliations
Abstract
It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of twenty days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication-competent viruses, have been limited. This report describes two patients with mild forms of the disease who shed replication-competent virus for 24 and 37 days, respectively, after symptom onset. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; cell culture; coronavirus.
. 2021 Apr 14.
doi: 10.1002/jmv.27021. Online ahead of print.
Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A Report of 2 Cases
Maria Cassia Mendes Correa[SUP] 1 2 [/SUP], Fabio E Leal[SUP] 3 4 [/SUP], Lucy S Villas Boas[SUP] 1 [/SUP], Steven S Witkin[SUP] 1 5 [/SUP], Anderson de Paula[SUP] 1 [/SUP], Tania Regina Tozetto Mendonza[SUP] 1 [/SUP], Noely Evangelista Ferreira[SUP] 1 [/SUP], Gislaine Curty[SUP] 4 [/SUP], Pedro Santos de Carvalho[SUP] 4 [/SUP], Lewis F Buss[SUP] 2 [/SUP], Silvia F Costa[SUP] 2 6 [/SUP], Flavia Mendes da Cunha Carvalho[SUP] 6 [/SUP], Joyce Kawakami[SUP] 7 [/SUP], Noemi Nosomi Taniwaki[SUP] 8 [/SUP], Heuder Paiao[SUP] 1 [/SUP], Joao Carlos da Silva Biz?rio[SUP] 3 [/SUP], Jaqueline Goes de Jesus[SUP] 2 6 [/SUP], Ester Cerdeira Sabino[SUP] 2 6 [/SUP], Camila Malta Romano[SUP] 1 [/SUP], Regina Maura Zetone Grepan[SUP] 3 [/SUP], Antonio Sesso[SUP] 6 [/SUP]
Affiliations
- PMID: 33851749
- DOI: 10.1002/jmv.27021
Abstract
It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of twenty days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication-competent viruses, have been limited. This report describes two patients with mild forms of the disease who shed replication-competent virus for 24 and 37 days, respectively, after symptom onset. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; cell culture; coronavirus.