tetano
Editor, Senior Moderator
J Med Virol
. 2020 Nov 23.
doi: 10.1002/jmv.26683. Online ahead of print.
Predictive Value of Cytokine/Chemokine Responses for the Disease Severity and Management in Children and Adult Cases with COVID-19
Yasemin Ozsurekci[SUP] 1 [/SUP], Kubra Aykac[SUP] 2 [/SUP], Ahmet Gorkem Er[SUP] 3 [/SUP], Burcin Halacli[SUP] 4 [/SUP], Mehmet Arasli[SUP] 5 [/SUP], Pembe Derin Oygar[SUP] 1 [/SUP], Sibel G?rlevik[SUP] 1 [/SUP], Burcu Ceylan Cura Yayla[SUP] 2 [/SUP], Jale Karakaya[SUP] 6 [/SUP], Alparslan Alp[SUP] 7 [/SUP], Arzu Topeli[SUP] 4 [/SUP], Ali B?lent Cengiz[SUP] 1 [/SUP], Murat Akova[SUP] 3 [/SUP], Mehmet Ceyhan[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The disease course of children with COVID-19 seems milder as compared with adults, however, actual reason of the pathogenesis still remains unclear. There is a growing interest on possible relationship between pathogenicity or disease severity and biomarkers including cytokines/chemokines.
Objectives: We wondered whether these biomarkers could be used for the prediction of the prognosis of COVID-19 and improving our understanding on the variations between pediatric and adult cases with COVID-19.
Study design: The acute phase serum levels of 25 cytokines and chemokines in the serum samples from 60 COVID-19 pediatric (n=30) and adult cases (n=30) including 20 severe/critically ill, 25 moderate and 15 mild patients and 30 healthy pediatric (n=15) and adult (n=15) volunteers were measured using commercially available fluorescent bead immunoassay and analyzed in combination with clinical data.
Results: Interferon gamma-induced protein 10 (IP-10) and macrophage inflammatory protein (MIP)-3β levels were significantly higher in patient cohort including pediatric and adult cases with COVID-19 when compared with all healthy volunteers (p= <0.001 in each) and whereas IP-10 levels were significantly higher in both pediatric and adult cases with severe disease course, MIP-3β were significantly lower in healthy controls. Additionally, IP-10 is an independent predictor for disease severity, particularly in children and IL-6 seems a relatively good predictor for disease severity in adults.
Conclusion: IP-10 and MIP-3β seem good research candidates to understand severity of COVID-19 in both pediatric and adult population and to investigate possible pathophysiological mechanism of COVID-19. This article is protected by copyright. All rights reserved.
Keywords: coronavirus; critically ill patient; pediatrics; treatment.
. 2020 Nov 23.
doi: 10.1002/jmv.26683. Online ahead of print.
Predictive Value of Cytokine/Chemokine Responses for the Disease Severity and Management in Children and Adult Cases with COVID-19
Yasemin Ozsurekci[SUP] 1 [/SUP], Kubra Aykac[SUP] 2 [/SUP], Ahmet Gorkem Er[SUP] 3 [/SUP], Burcin Halacli[SUP] 4 [/SUP], Mehmet Arasli[SUP] 5 [/SUP], Pembe Derin Oygar[SUP] 1 [/SUP], Sibel G?rlevik[SUP] 1 [/SUP], Burcu Ceylan Cura Yayla[SUP] 2 [/SUP], Jale Karakaya[SUP] 6 [/SUP], Alparslan Alp[SUP] 7 [/SUP], Arzu Topeli[SUP] 4 [/SUP], Ali B?lent Cengiz[SUP] 1 [/SUP], Murat Akova[SUP] 3 [/SUP], Mehmet Ceyhan[SUP] 1 [/SUP]
Affiliations
- PMID: 33225509
- DOI: 10.1002/jmv.26683
Abstract
Background: The disease course of children with COVID-19 seems milder as compared with adults, however, actual reason of the pathogenesis still remains unclear. There is a growing interest on possible relationship between pathogenicity or disease severity and biomarkers including cytokines/chemokines.
Objectives: We wondered whether these biomarkers could be used for the prediction of the prognosis of COVID-19 and improving our understanding on the variations between pediatric and adult cases with COVID-19.
Study design: The acute phase serum levels of 25 cytokines and chemokines in the serum samples from 60 COVID-19 pediatric (n=30) and adult cases (n=30) including 20 severe/critically ill, 25 moderate and 15 mild patients and 30 healthy pediatric (n=15) and adult (n=15) volunteers were measured using commercially available fluorescent bead immunoassay and analyzed in combination with clinical data.
Results: Interferon gamma-induced protein 10 (IP-10) and macrophage inflammatory protein (MIP)-3β levels were significantly higher in patient cohort including pediatric and adult cases with COVID-19 when compared with all healthy volunteers (p= <0.001 in each) and whereas IP-10 levels were significantly higher in both pediatric and adult cases with severe disease course, MIP-3β were significantly lower in healthy controls. Additionally, IP-10 is an independent predictor for disease severity, particularly in children and IL-6 seems a relatively good predictor for disease severity in adults.
Conclusion: IP-10 and MIP-3β seem good research candidates to understand severity of COVID-19 in both pediatric and adult population and to investigate possible pathophysiological mechanism of COVID-19. This article is protected by copyright. All rights reserved.
Keywords: coronavirus; critically ill patient; pediatrics; treatment.