tetano
Editor, Senior Moderator
J Med Virol
. 2022 May 3.
doi: 10.1002/jmv.27822. Online ahead of print.
Persistently positive SARS-CoV-2 specific IgM during one-year follow-up
Marcela Helena Gambim Fonseca[SUP] 1 [/SUP], Maria Francilene Souza Silva[SUP] 1 [/SUP], Ana Carolina Matias Dinelly Pinto[SUP] 1 [/SUP], Amanda Campelo Lima de Melo[SUP] 1 [/SUP], Fátima de Cássia Evangelista de Oliveira[SUP] 1 [/SUP], Fernanda Montenegro de Carvalho Araújo[SUP] 1 [/SUP], Luiz Odorico Monteiro de Andrade[SUP] 1 [/SUP]
Affiliations
Abstract
IgM antibodies typically appear in the early stage of infection and have a short maintenance time, so IgM is frequently used as a diagnostic criterion for acute or recent disease [1]. However, unconventional IgM specific responses have been described in SARS-COV-2 infection, raising doubts about the use of IgM as a biomarker for COVID-19 and the role of this antibody in immunity to SARS-CoV-2 [1,2]. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus; Humoral immuity; Immune responses; Immunoglobin; Virus classification.
. 2022 May 3.
doi: 10.1002/jmv.27822. Online ahead of print.
Persistently positive SARS-CoV-2 specific IgM during one-year follow-up
Marcela Helena Gambim Fonseca[SUP] 1 [/SUP], Maria Francilene Souza Silva[SUP] 1 [/SUP], Ana Carolina Matias Dinelly Pinto[SUP] 1 [/SUP], Amanda Campelo Lima de Melo[SUP] 1 [/SUP], Fátima de Cássia Evangelista de Oliveira[SUP] 1 [/SUP], Fernanda Montenegro de Carvalho Araújo[SUP] 1 [/SUP], Luiz Odorico Monteiro de Andrade[SUP] 1 [/SUP]
Affiliations
- PMID: 35505640
- DOI: 10.1002/jmv.27822
Abstract
IgM antibodies typically appear in the early stage of infection and have a short maintenance time, so IgM is frequently used as a diagnostic criterion for acute or recent disease [1]. However, unconventional IgM specific responses have been described in SARS-COV-2 infection, raising doubts about the use of IgM as a biomarker for COVID-19 and the role of this antibody in immunity to SARS-CoV-2 [1,2]. This article is protected by copyright. All rights reserved.
Keywords: Coronavirus; Humoral immuity; Immune responses; Immunoglobin; Virus classification.