tetano
Editor, Senior Moderator
J Med Virol. 2020 Apr 24.
doi: 10.1002/jmv.25940. Online ahead of print.
Persistent Viral RNA Positivity During Recovery Period of a Patient With SARS-CoV-2 Infection
Jian-Rong Yang[SUP] 1 [/SUP], Dao-Ting Deng[SUP] 2 [/SUP], Nan Wu[SUP] 3 [/SUP], Bin Yang[SUP] 4 [/SUP], Hong-Juan Li[SUP] 5 [/SUP], Xiao-Ben Pan[SUP] 5 [/SUP]
Affiliations
Abstract
As an emerging infectious disease, the clinical course and virological course of SARS-CoV-2 infection remain to be further investigated. In this case report, we described a case of SARS-CoV-2 infection with clinical course more than two months. This patient had recovered from the pneumonia after treatment. The viral RNA of throat swabs became negative and the viral specific antibodies were produced during recovery period. However, the viral RNA reappeared and additionally persisted in throat swabs for more than 40 days. In addition, the viral RNA was detected in multiple types of specimens with extremely high titers in the saliva. In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. The coexistence of viral RNA and viral specific antibodies may imply an immune evasion of SARAS-CoV-2 from host's immune system. This article is protected by copyright. All rights reserved.
doi: 10.1002/jmv.25940. Online ahead of print.
Persistent Viral RNA Positivity During Recovery Period of a Patient With SARS-CoV-2 Infection
Jian-Rong Yang[SUP] 1 [/SUP], Dao-Ting Deng[SUP] 2 [/SUP], Nan Wu[SUP] 3 [/SUP], Bin Yang[SUP] 4 [/SUP], Hong-Juan Li[SUP] 5 [/SUP], Xiao-Ben Pan[SUP] 5 [/SUP]
Affiliations
- PMID: 32330293
- DOI: 10.1002/jmv.25940
Abstract
As an emerging infectious disease, the clinical course and virological course of SARS-CoV-2 infection remain to be further investigated. In this case report, we described a case of SARS-CoV-2 infection with clinical course more than two months. This patient had recovered from the pneumonia after treatment. The viral RNA of throat swabs became negative and the viral specific antibodies were produced during recovery period. However, the viral RNA reappeared and additionally persisted in throat swabs for more than 40 days. In addition, the viral RNA was detected in multiple types of specimens with extremely high titers in the saliva. In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. The coexistence of viral RNA and viral specific antibodies may imply an immune evasion of SARAS-CoV-2 from host's immune system. This article is protected by copyright. All rights reserved.