tetano
Editor, Senior Moderator
J Med Virol
. 2022 May 4.
doi: 10.1002/jmv.27832. Online ahead of print.
Persistent high-level shedding of cultivable SARS-CoV-2 Delta virus 33 days after onset of COVID-19 in a hospitalized patient with pneumonia
Ki Wook Kim[SUP] 1 2 [/SUP], Xinye Wang[SUP] 1 3 [/SUP], Anurag Adhikari[SUP] 3 4 [/SUP], Malinna Yeang[SUP] 1 [/SUP], Frances Jenkins[SUP] 5 [/SUP], Zin Naing[SUP] 1 [/SUP], Gregory J Walker[SUP] 1 3 [/SUP], Charles S P Foster[SUP] 1 3 [/SUP], Sacha Stelzer-Braid[SUP] 1 3 [/SUP], Ira Deveson[SUP] 6 7 [/SUP], Maria E Craig[SUP] 1 2 8 [/SUP], Nicodemus Tedla[SUP] 3 [/SUP], Rowena A Bull[SUP] 3 4 [/SUP], Marianne Martinello[SUP] 3 4 [/SUP], Angie N Pinto[SUP] 5 [/SUP], Raymond Chan[SUP] 5 [/SUP], Stuart Turville[SUP] 3 4 [/SUP], William D Rawlinson[SUP] 1 2 3 9 [/SUP], Sebastiaan van Hal[SUP] 5 10 [/SUP]
Affiliations
Abstract
Here we report prolonged viral shedding for over 29 days of SARS-CoV-2 Delta variant (B.1.617.2) in six patients with severe coronavirus disease (COVID-19) admitted to the intensive care unit (ICU). One patient remained culture positive 33 days after onset of disease. These features, including the persistence of high viral load (Ct < 30) in these patients, present new uncertainties concerning the safe discharge of patients from isolation into the general inpatient population. Prolonged high-level shedding and culture positivity of SARS-CoV-2 Delta variant for more than 29 days in hospitalized patients with severe COVID-19 presents new diagnostic and management problems. Viral culture results remain indicative of ongoing risk of transmission in the absence of functional humoral immune responses. This article is protected by copyright. All rights reserved.
. 2022 May 4.
doi: 10.1002/jmv.27832. Online ahead of print.
Persistent high-level shedding of cultivable SARS-CoV-2 Delta virus 33 days after onset of COVID-19 in a hospitalized patient with pneumonia
Ki Wook Kim[SUP] 1 2 [/SUP], Xinye Wang[SUP] 1 3 [/SUP], Anurag Adhikari[SUP] 3 4 [/SUP], Malinna Yeang[SUP] 1 [/SUP], Frances Jenkins[SUP] 5 [/SUP], Zin Naing[SUP] 1 [/SUP], Gregory J Walker[SUP] 1 3 [/SUP], Charles S P Foster[SUP] 1 3 [/SUP], Sacha Stelzer-Braid[SUP] 1 3 [/SUP], Ira Deveson[SUP] 6 7 [/SUP], Maria E Craig[SUP] 1 2 8 [/SUP], Nicodemus Tedla[SUP] 3 [/SUP], Rowena A Bull[SUP] 3 4 [/SUP], Marianne Martinello[SUP] 3 4 [/SUP], Angie N Pinto[SUP] 5 [/SUP], Raymond Chan[SUP] 5 [/SUP], Stuart Turville[SUP] 3 4 [/SUP], William D Rawlinson[SUP] 1 2 3 9 [/SUP], Sebastiaan van Hal[SUP] 5 10 [/SUP]
Affiliations
- PMID: 35509147
- DOI: 10.1002/jmv.27832
Abstract
Here we report prolonged viral shedding for over 29 days of SARS-CoV-2 Delta variant (B.1.617.2) in six patients with severe coronavirus disease (COVID-19) admitted to the intensive care unit (ICU). One patient remained culture positive 33 days after onset of disease. These features, including the persistence of high viral load (Ct < 30) in these patients, present new uncertainties concerning the safe discharge of patients from isolation into the general inpatient population. Prolonged high-level shedding and culture positivity of SARS-CoV-2 Delta variant for more than 29 days in hospitalized patients with severe COVID-19 presents new diagnostic and management problems. Viral culture results remain indicative of ongoing risk of transmission in the absence of functional humoral immune responses. This article is protected by copyright. All rights reserved.