tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jan 21.
doi: 10.1002/jmv.27606. Online ahead of print.
Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID-19 infections during the third trimester of pregnancy: A retrospective study in Metz, France
Guillaume Schmitt[SUP] 1 2 [/SUP], Sary Labdouni[SUP] 2 [/SUP], Rachid Soulimani[SUP] 1 [/SUP], Catherine Delamare[SUP] 2 [/SUP], Jaouad Bouayed[SUP] 1 [/SUP]
Affiliations
Abstract
It is believed that the subtle equilibrium between tolerance and immunity during the unique biological state of pregnancy, which is characterized by further physiological and hormonal changes, rends pregnant women more vulnerable to the coronavirus disease 2019 (COVID-19). In this retrospective study, confirmed COVID-19-positive pregnant women (n = 15) during their third trimester, comprising asymptomatic (n = 7) and mild symptomatic (n= 8), and healthy pregnant controls (n= 20) were enrolled between June 1[SUP]st[/SUP] 2020 and 1[SUP]st[/SUP] June 2021 from the Hospital CHR Metz-Thionville in Metz, France. Vitamin D concentrations, C-reactive protein (CRP) and oxidative stress markers including superoxide dismutase (SOD), catalase (CAT), reduced (GSH) and oxidized (GSSG) glutathione levels, hydrogen peroxide (H[SUB]2[/SUB] O[SUB]2[/SUB] ), and the total antioxidant capacity, measured the ferric reducing ability of plasma (FRAP), were evaluated in the serum of patients and controls. Results showed that all pregnant women (patients and controls) enrolled in this study were vitamin D deficient (< 20 ng /mL). However, mild COVID-19 pregnant women were severely vitamin D deficient (< 12 ng / mL), which may suggest a link between vitamin D deficiency and the symptomatology of COVID-19 illness in singleton pregnancy. No differences between the levels of CRP and the majority of the studied oxidative stress markers in COVID-19-positive pregnant women (asymptomatic and/or mildly symptomatic patients) versus COVID-19-negative pregnant women were found, suggesting the absence or a low magnitude of oxidative stress in pregnant women with COVID-19. This may also explain the absence of severe courses of COVID-19 infection. More studies are warranted to investigate the role of vitamin D supplementation and antioxidant-rich diets in the prevention against severe forms of COVID-19 in pregnant women. This article is protected by copyright. All rights reserved.
Keywords: C-reactive protein (CRP); COVID-19; Oxidative stress; Pregnancy; SARS-CoV-2; Vitamin D.
. 2022 Jan 21.
doi: 10.1002/jmv.27606. Online ahead of print.
Oxidative stress status and vitamin D levels of asymptomatic to mild symptomatic COVID-19 infections during the third trimester of pregnancy: A retrospective study in Metz, France
Guillaume Schmitt[SUP] 1 2 [/SUP], Sary Labdouni[SUP] 2 [/SUP], Rachid Soulimani[SUP] 1 [/SUP], Catherine Delamare[SUP] 2 [/SUP], Jaouad Bouayed[SUP] 1 [/SUP]
Affiliations
- PMID: 35060637
- DOI: 10.1002/jmv.27606
Abstract
It is believed that the subtle equilibrium between tolerance and immunity during the unique biological state of pregnancy, which is characterized by further physiological and hormonal changes, rends pregnant women more vulnerable to the coronavirus disease 2019 (COVID-19). In this retrospective study, confirmed COVID-19-positive pregnant women (n = 15) during their third trimester, comprising asymptomatic (n = 7) and mild symptomatic (n= 8), and healthy pregnant controls (n= 20) were enrolled between June 1[SUP]st[/SUP] 2020 and 1[SUP]st[/SUP] June 2021 from the Hospital CHR Metz-Thionville in Metz, France. Vitamin D concentrations, C-reactive protein (CRP) and oxidative stress markers including superoxide dismutase (SOD), catalase (CAT), reduced (GSH) and oxidized (GSSG) glutathione levels, hydrogen peroxide (H[SUB]2[/SUB] O[SUB]2[/SUB] ), and the total antioxidant capacity, measured the ferric reducing ability of plasma (FRAP), were evaluated in the serum of patients and controls. Results showed that all pregnant women (patients and controls) enrolled in this study were vitamin D deficient (< 20 ng /mL). However, mild COVID-19 pregnant women were severely vitamin D deficient (< 12 ng / mL), which may suggest a link between vitamin D deficiency and the symptomatology of COVID-19 illness in singleton pregnancy. No differences between the levels of CRP and the majority of the studied oxidative stress markers in COVID-19-positive pregnant women (asymptomatic and/or mildly symptomatic patients) versus COVID-19-negative pregnant women were found, suggesting the absence or a low magnitude of oxidative stress in pregnant women with COVID-19. This may also explain the absence of severe courses of COVID-19 infection. More studies are warranted to investigate the role of vitamin D supplementation and antioxidant-rich diets in the prevention against severe forms of COVID-19 in pregnant women. This article is protected by copyright. All rights reserved.
Keywords: C-reactive protein (CRP); COVID-19; Oxidative stress; Pregnancy; SARS-CoV-2; Vitamin D.