tetano
Editor, Senior Moderator
J Med Virol
. 2021 Jun 29.
doi: 10.1002/jmv.27166. Online ahead of print.
Long-term monitoring of the development and extinction of IgA and IgG responses to SARS-CoV-2 infection
Andrei Ivanov[SUP] 1 2 [/SUP], Elena Semenova[SUP] 3 [/SUP]
Affiliations
Abstract
Despite the great interest of scientific community in the behavior of the human body after contact with the new coronavirus SARS-CoV-2 a long-term (more than six months) monitoring of immunological status of Covid-19 patients with varying severity degrees and of the people with a low SARS-CoV-2 viral load is practically absent. The aim of this study is a 9-month monitoring SARS-CoV-2 infection immune response development and extinction using quantitative assessment of IgA and IgG levels in the blood of healthy donors living in the context of the coronavirus pandemic and of the patients who have undergone COVID-19. The project involved 180 volunteers of whom 51 persons (28.33%) fell ill with COVID-19 during the observation period. All people who underwent Covid-19 developed a stable humoral immune response but their individual immune status had a number of features. 39.22% (20 of 51 people) of project participants diagnosed with Covid-19 showed an unusual change in plasma anti-SARS-CoV-2 IgA levels. Relatively high levels of IgA (ratio ~ 3) after recovery persisted for a long time (more than six months). In one third (17 of 51 people) of Covid-19 patients, the IgA level exceeded the IgG level. IgA antibodies appeared earlier and showed a stronger and more robust response to the SARS-CoV-2 virus than IgG. Increased levels of anti-SARS-CoV-2 IgA (ratio from 0.8 to 2.36) throughout the observation period were recorded in 28 of 180 project participants (15.56%) of whom only one person fell ill with Covid-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; anty-SARS-CoV-2 immunoglobulins; humoral immunity; long-term monitoring.
. 2021 Jun 29.
doi: 10.1002/jmv.27166. Online ahead of print.
Long-term monitoring of the development and extinction of IgA and IgG responses to SARS-CoV-2 infection
Andrei Ivanov[SUP] 1 2 [/SUP], Elena Semenova[SUP] 3 [/SUP]
Affiliations
- PMID: 34185312
- DOI: 10.1002/jmv.27166
Abstract
Despite the great interest of scientific community in the behavior of the human body after contact with the new coronavirus SARS-CoV-2 a long-term (more than six months) monitoring of immunological status of Covid-19 patients with varying severity degrees and of the people with a low SARS-CoV-2 viral load is practically absent. The aim of this study is a 9-month monitoring SARS-CoV-2 infection immune response development and extinction using quantitative assessment of IgA and IgG levels in the blood of healthy donors living in the context of the coronavirus pandemic and of the patients who have undergone COVID-19. The project involved 180 volunteers of whom 51 persons (28.33%) fell ill with COVID-19 during the observation period. All people who underwent Covid-19 developed a stable humoral immune response but their individual immune status had a number of features. 39.22% (20 of 51 people) of project participants diagnosed with Covid-19 showed an unusual change in plasma anti-SARS-CoV-2 IgA levels. Relatively high levels of IgA (ratio ~ 3) after recovery persisted for a long time (more than six months). In one third (17 of 51 people) of Covid-19 patients, the IgA level exceeded the IgG level. IgA antibodies appeared earlier and showed a stronger and more robust response to the SARS-CoV-2 virus than IgG. Increased levels of anti-SARS-CoV-2 IgA (ratio from 0.8 to 2.36) throughout the observation period were recorded in 28 of 180 project participants (15.56%) of whom only one person fell ill with Covid-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; anty-SARS-CoV-2 immunoglobulins; humoral immunity; long-term monitoring.