tetano
Editor, Senior Moderator
J Med Virol. 2020 Apr 28. doi: 10.1002/jmv.25946. [Epub ahead of print]
Long-term Coexistence of SARS-CoV-2 with Antibody Response in COVID-19 Patients.
Wang B[SUP]1[/SUP], Wang L[SUP]1[/SUP], Kong X[SUP]1[/SUP], Geng J[SUP]1[/SUP], Xiao D[SUP]1[/SUP], Ma C[SUP]2[/SUP], Jiang XM[SUP]1[/SUP], Wang PH[SUP]2[/SUP].
Author information
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection needs to be determined. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SRAS-CoV-2 and virus-specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient who did not produce any SARS-CoV-2-bound IgG successfully cleared SARS-CoV-2 after 46 days of illness, revealing that without antibody-mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS-CoV-2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS-CoV-2 clearance, especially in non-severe cases. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Antibody; COVID-19; IgG; Immunity; SARS-CoV-2
PMID:32343415DOI:10.1002/jmv.25946
Long-term Coexistence of SARS-CoV-2 with Antibody Response in COVID-19 Patients.
Wang B[SUP]1[/SUP], Wang L[SUP]1[/SUP], Kong X[SUP]1[/SUP], Geng J[SUP]1[/SUP], Xiao D[SUP]1[/SUP], Ma C[SUP]2[/SUP], Jiang XM[SUP]1[/SUP], Wang PH[SUP]2[/SUP].
Author information
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection needs to be determined. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SRAS-CoV-2 and virus-specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient who did not produce any SARS-CoV-2-bound IgG successfully cleared SARS-CoV-2 after 46 days of illness, revealing that without antibody-mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS-CoV-2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS-CoV-2 clearance, especially in non-severe cases. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Antibody; COVID-19; IgG; Immunity; SARS-CoV-2
PMID:32343415DOI:10.1002/jmv.25946