tetano
Editor, Senior Moderator
J Med Virol
. 2022 Jul 28.
doi: 10.1002/jmv.28033. Online ahead of print.
Initial Introduction and Spread of the SARS-CoV-2 AY.4.2.1 Delta Variant in Bulgaria, a Genomic Insight
Ivailo Alexiev[SUP] 1 [/SUP], Marta Giovanetti[SUP] 2 [/SUP], Eleonora Cella[SUP] 3 [/SUP], Ivan Ivanov[SUP] 1 [/SUP], Ivan Stoikov[SUP] 1 [/SUP], Deyan Donchev[SUP] 1 [/SUP], Lubomira Grigorova[SUP] 1 [/SUP], Anna Gancheva[SUP] 1 [/SUP], Reneta Dimitrova[SUP] 1 [/SUP], Nelly Korsun[SUP] 1 [/SUP], Ivelina Trifonova[SUP] 1 [/SUP], Ivva Philipova[SUP] 1 [/SUP], Veselin Dobrinov[SUP] 1 [/SUP], Iliana Grigorova[SUP] 1 [/SUP], Todor Kantardjiev[SUP] 1 [/SUP], Iva Christova[SUP] 1 [/SUP], Massimo Ciccozzi[SUP] 4 [/SUP]
Affiliations
Abstract
The evolution of the emerging SARS-CoV-2 variants carrying mutations in the spike protein raises concerns about the possibility of accelerated transmission in the ever-evolving COVID-19 pandemic worldwide. AY.4.2, a sublineage of the Delta variant, was considered a variant under investigation (VUI) and also gained the nickname 'Delta Plus', due to its extra mutations, Y145H and A222V. In this study, using genomic epidemiology, we provide the first insights of the introduction of AY.4.2 in Bulgaria and the AY.4.2.1 sublineage that found larger dissemination only in Bulgaria and the United Kingdom. This article is protected by copyright. All rights reserved.
Keywords: Evolution, Epidemiology; SARS coronavirus; Virus classification, Mutation/Mutation rate.
. 2022 Jul 28.
doi: 10.1002/jmv.28033. Online ahead of print.
Initial Introduction and Spread of the SARS-CoV-2 AY.4.2.1 Delta Variant in Bulgaria, a Genomic Insight
Ivailo Alexiev[SUP] 1 [/SUP], Marta Giovanetti[SUP] 2 [/SUP], Eleonora Cella[SUP] 3 [/SUP], Ivan Ivanov[SUP] 1 [/SUP], Ivan Stoikov[SUP] 1 [/SUP], Deyan Donchev[SUP] 1 [/SUP], Lubomira Grigorova[SUP] 1 [/SUP], Anna Gancheva[SUP] 1 [/SUP], Reneta Dimitrova[SUP] 1 [/SUP], Nelly Korsun[SUP] 1 [/SUP], Ivelina Trifonova[SUP] 1 [/SUP], Ivva Philipova[SUP] 1 [/SUP], Veselin Dobrinov[SUP] 1 [/SUP], Iliana Grigorova[SUP] 1 [/SUP], Todor Kantardjiev[SUP] 1 [/SUP], Iva Christova[SUP] 1 [/SUP], Massimo Ciccozzi[SUP] 4 [/SUP]
Affiliations
- PMID: 35902787
- DOI: 10.1002/jmv.28033
Abstract
The evolution of the emerging SARS-CoV-2 variants carrying mutations in the spike protein raises concerns about the possibility of accelerated transmission in the ever-evolving COVID-19 pandemic worldwide. AY.4.2, a sublineage of the Delta variant, was considered a variant under investigation (VUI) and also gained the nickname 'Delta Plus', due to its extra mutations, Y145H and A222V. In this study, using genomic epidemiology, we provide the first insights of the introduction of AY.4.2 in Bulgaria and the AY.4.2.1 sublineage that found larger dissemination only in Bulgaria and the United Kingdom. This article is protected by copyright. All rights reserved.
Keywords: Evolution, Epidemiology; SARS coronavirus; Virus classification, Mutation/Mutation rate.