tetano
Editor, Senior Moderator
J Med Virol. 2020 Feb 28. doi: 10.1002/jmv.25736. [Epub ahead of print] [h=1]Development of epitope-based peptide vaccine against novel Coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.[/h]
Bhattacharya M[SUP]1,[/SUP][SUP]2[/SUP], Ranjan Sharma A[SUP]1[/SUP], Patra P[SUP]2[/SUP], Ghosh P[SUP]2[/SUP], Sharma G[SUP]3[/SUP], Chandra Patra B[SUP]2[/SUP], Lee SS[SUP]1[/SUP], Chakraborty C[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Recently, a novel Coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to the SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on Toll-Like Receptor (TLR)-5 to get binding affinity. Therefore, in order to provide a fast immunogenic profile of these epitopes we performed immunoinformatics analysis so that rapid development of vaccine might bring this disastrous situation to the end earlier. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] SARS-COV-2; epitopes; immunoinformatics; vaccine
PMID: 32108359 DOI: 10.1002/jmv.25736
Bhattacharya M[SUP]1,[/SUP][SUP]2[/SUP], Ranjan Sharma A[SUP]1[/SUP], Patra P[SUP]2[/SUP], Ghosh P[SUP]2[/SUP], Sharma G[SUP]3[/SUP], Chandra Patra B[SUP]2[/SUP], Lee SS[SUP]1[/SUP], Chakraborty C[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Recently, a novel Coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to the SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on Toll-Like Receptor (TLR)-5 to get binding affinity. Therefore, in order to provide a fast immunogenic profile of these epitopes we performed immunoinformatics analysis so that rapid development of vaccine might bring this disastrous situation to the end earlier. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] SARS-COV-2; epitopes; immunoinformatics; vaccine
PMID: 32108359 DOI: 10.1002/jmv.25736