tetano
Editor, Senior Moderator
J Med Virol. 2020 May 6. doi: 10.1002/jmv.25980. [Epub ahead of print]
DC/L-SIGNs of Hope in the COVID-19 Pandemic.
Brufsky A[SUP]1[/SUP], Lotze MT[SUP]2[/SUP].
Author information
Abstract
In a rapidly evolving pandemic such as COVID-19, theories which help unify disparate pre-clinical and clinical observations would be useful. The current pandemic and its pleotropic effects can be explained in part by interaction between SARS-CoV-2 spike protein S, the ACE2/L-SIGN/CD209 receptor on the type II alveolar cell of the lung, and the DC-SIGN receptor on the respiratory dendritic cell (DC) and associated endothelial cells. Infection of the DC by SARS-CoV-2 can potentially explain the exuberant distal immunopathology seen in COVID-19. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Glycoproteins; Immune response; SARS Coronavirus
PMID:32374430DOI:10.1002/jmv.25980
DC/L-SIGNs of Hope in the COVID-19 Pandemic.
Brufsky A[SUP]1[/SUP], Lotze MT[SUP]2[/SUP].
Author information
Abstract
In a rapidly evolving pandemic such as COVID-19, theories which help unify disparate pre-clinical and clinical observations would be useful. The current pandemic and its pleotropic effects can be explained in part by interaction between SARS-CoV-2 spike protein S, the ACE2/L-SIGN/CD209 receptor on the type II alveolar cell of the lung, and the DC-SIGN receptor on the respiratory dendritic cell (DC) and associated endothelial cells. Infection of the DC by SARS-CoV-2 can potentially explain the exuberant distal immunopathology seen in COVID-19. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Glycoproteins; Immune response; SARS Coronavirus
PMID:32374430DOI:10.1002/jmv.25980