tetano
Editor, Senior Moderator
J Med Virol
. 2023 Jan 18.
doi: 10.1002/jmv.28498. Online ahead of print.
Co-circulation of A(H3N2) and B/Victoria increased morbidity in hospitalized patients in the 2019-2020 A(H1N1)pdm09 predominant influenza season in Israel
Menucha Jurkowicz[SUP] 1 2 [/SUP], Ital Nemet[SUP] 3 [/SUP], Nofar Atari[SUP] 3 [/SUP], Ilana S Fratty[SUP] 3 4 [/SUP], Limor Kliker[SUP] 1 3 [/SUP], Hilda Sherbany[SUP] 3 [/SUP], Nathan Keller[SUP] 5 [/SUP], Eugene Leibovitz[SUP] 2 [/SUP], Ella Mendelson[SUP] 1 3 [/SUP], Michal Mandelboim[SUP] 1 3 [/SUP], Michal Stein[SUP] 2 6 [/SUP]
Affiliations
Abstract
Community surveillance found the 2019-2020 A(H1N1)pdm09 predominant influenza season in Israel to be a high intensity season with an early and steep morbidity peak. In order to further characterize disease severity in the 2019-2020 season, we analyzed a cohort of hospitalized patients with laboratory confirmed influenza from this season (n = 636). Quantitative polymerase chain reaction was performed on clinical samples to detect the presence of influenza. Demographic, clinical and laboratory data were retrieved via electronic health records and MDClone. Electronic health records were accessed to obtain data on intensive care unit patients, missing data and for data verification purposes. Univariate analysis was performed to compare demographic, comorbidity and clinical characteristics across the three influenza strains. The A(H1N1)pdm09 predominant 2019-2020 influenza season in Israel was characterized by an early and steep morbidity peak, vaccine delays and shortages, and with the A(H3N2) and B/Victoria strains disproportionately targeting children and young adults, most probably due to reduced immunity to these strains. A greater proportion of children < 5 years infected with A(H3N2) and B/Victoria developed severe influenza compared with those infected with A(H1N1)pdm09. Our study emphasizes the vulnerability of infants and young children in the face of rapidly evolving influenza strains and underscores the importance of influenza prevention measures in this population. This article is protected by copyright. All rights reserved.
Keywords: A(H1N1)pdm09; A(H3N2); B/Victoria; Influenza; respiratory virus.
. 2023 Jan 18.
doi: 10.1002/jmv.28498. Online ahead of print.
Co-circulation of A(H3N2) and B/Victoria increased morbidity in hospitalized patients in the 2019-2020 A(H1N1)pdm09 predominant influenza season in Israel
Menucha Jurkowicz[SUP] 1 2 [/SUP], Ital Nemet[SUP] 3 [/SUP], Nofar Atari[SUP] 3 [/SUP], Ilana S Fratty[SUP] 3 4 [/SUP], Limor Kliker[SUP] 1 3 [/SUP], Hilda Sherbany[SUP] 3 [/SUP], Nathan Keller[SUP] 5 [/SUP], Eugene Leibovitz[SUP] 2 [/SUP], Ella Mendelson[SUP] 1 3 [/SUP], Michal Mandelboim[SUP] 1 3 [/SUP], Michal Stein[SUP] 2 6 [/SUP]
Affiliations
- PMID: 36653733
- DOI: 10.1002/jmv.28498
Abstract
Community surveillance found the 2019-2020 A(H1N1)pdm09 predominant influenza season in Israel to be a high intensity season with an early and steep morbidity peak. In order to further characterize disease severity in the 2019-2020 season, we analyzed a cohort of hospitalized patients with laboratory confirmed influenza from this season (n = 636). Quantitative polymerase chain reaction was performed on clinical samples to detect the presence of influenza. Demographic, clinical and laboratory data were retrieved via electronic health records and MDClone. Electronic health records were accessed to obtain data on intensive care unit patients, missing data and for data verification purposes. Univariate analysis was performed to compare demographic, comorbidity and clinical characteristics across the three influenza strains. The A(H1N1)pdm09 predominant 2019-2020 influenza season in Israel was characterized by an early and steep morbidity peak, vaccine delays and shortages, and with the A(H3N2) and B/Victoria strains disproportionately targeting children and young adults, most probably due to reduced immunity to these strains. A greater proportion of children < 5 years infected with A(H3N2) and B/Victoria developed severe influenza compared with those infected with A(H1N1)pdm09. Our study emphasizes the vulnerability of infants and young children in the face of rapidly evolving influenza strains and underscores the importance of influenza prevention measures in this population. This article is protected by copyright. All rights reserved.
Keywords: A(H1N1)pdm09; A(H3N2); B/Victoria; Influenza; respiratory virus.