tetano
Editor, Senior Moderator
J Med Virol
. 2021 Jan 28.
doi: 10.1002/jmv.26828. Online ahead of print.
Clinical characteristics and outcomes of COVID-19 in people living with HIV in Belgium: A multicenter, retrospective cohort
Rakan Nasreddine[SUP] 1 [/SUP], Eric Florence[SUP] 2 [/SUP], Michel Moutschen[SUP] 3 [/SUP], Jean-Cyr Yombi[SUP] 4 [/SUP], Jean-Christophe Goffard[SUP] 5 [/SUP], Inge Derdelinckx[SUP] 6 [/SUP], Patrick Lacor[SUP] 7 [/SUP], Linos Vandekerckhove[SUP] 8 [/SUP], Peter Messiaen[SUP] 9 [/SUP], Stefaan Vandecasteele[SUP] 10 [/SUP], Marc Delforge[SUP] 1 [/SUP], St?phane De Wit[SUP] 1 [/SUP], Belgian Research on AIDS and HIV Consortium (BREACH)
Affiliations
Abstract
The aim of this study was to describe the clinical characteristics and outcomes of coronavirus disease 2019 (COVID-19) among people living with HIV (PLWH) in Belgium. We performed a retrospective multicenter cohort analysis of PLWH with either laboratory-confirmed, radiologically-diagnosed, or clinically suspected COVID-19 between Feb 15, 2020 and May 31, 2020. The primary endpoint was outcome of COVID-19. Secondary endpoints included rate of hospitalization and length of hospital stay and rate of Intensive Care Unit (ICU) admission and mechanical ventilation. One hundred and one patients were included in this study. Patients were categorized as having either laboratory-confirmed (n = 65), radiologically-diagnosed (n = 3), or clinically suspected COVID-19 (n = 33). The median age was 51.3 years (IQR 41.3 - 57.3) and 44% were female. Ninety-four percent of patients were virologically suppressed and 67% had a CD4[SUP]+[/SUP] cell count ≥500 cells/?L. Overall, 46% of patients required hospitalization and the median length of hospital stay was 6 days (IQR 3 - 15). Age ≥50 years, Black Sub-Saharan African patients, and being on an integrase strand transfer inhibitor-based regimen were associated with being hospitalized. ICU admission and mechanical ventilation was required for 15% and 10% of all patients respectively. Overall, 9% of patients died while 78 (77%) patients made a full recovery. HIV patients with COVID-19 experienced a high degree of hospitalization despite having elevated CD4[SUP]+[/SUP] cell counts and a high rate of virologic suppression. Matched case-control studies are warranted to measure the impact that HIV may have on patients with COVID-19. This article is protected by copyright. All rights reserved.
Keywords: Belgium; COVID-19; clinical characteristics; outcomes; people living with HIV.
. 2021 Jan 28.
doi: 10.1002/jmv.26828. Online ahead of print.
Clinical characteristics and outcomes of COVID-19 in people living with HIV in Belgium: A multicenter, retrospective cohort
Rakan Nasreddine[SUP] 1 [/SUP], Eric Florence[SUP] 2 [/SUP], Michel Moutschen[SUP] 3 [/SUP], Jean-Cyr Yombi[SUP] 4 [/SUP], Jean-Christophe Goffard[SUP] 5 [/SUP], Inge Derdelinckx[SUP] 6 [/SUP], Patrick Lacor[SUP] 7 [/SUP], Linos Vandekerckhove[SUP] 8 [/SUP], Peter Messiaen[SUP] 9 [/SUP], Stefaan Vandecasteele[SUP] 10 [/SUP], Marc Delforge[SUP] 1 [/SUP], St?phane De Wit[SUP] 1 [/SUP], Belgian Research on AIDS and HIV Consortium (BREACH)
Affiliations
- PMID: 33506953
- DOI: 10.1002/jmv.26828
Abstract
The aim of this study was to describe the clinical characteristics and outcomes of coronavirus disease 2019 (COVID-19) among people living with HIV (PLWH) in Belgium. We performed a retrospective multicenter cohort analysis of PLWH with either laboratory-confirmed, radiologically-diagnosed, or clinically suspected COVID-19 between Feb 15, 2020 and May 31, 2020. The primary endpoint was outcome of COVID-19. Secondary endpoints included rate of hospitalization and length of hospital stay and rate of Intensive Care Unit (ICU) admission and mechanical ventilation. One hundred and one patients were included in this study. Patients were categorized as having either laboratory-confirmed (n = 65), radiologically-diagnosed (n = 3), or clinically suspected COVID-19 (n = 33). The median age was 51.3 years (IQR 41.3 - 57.3) and 44% were female. Ninety-four percent of patients were virologically suppressed and 67% had a CD4[SUP]+[/SUP] cell count ≥500 cells/?L. Overall, 46% of patients required hospitalization and the median length of hospital stay was 6 days (IQR 3 - 15). Age ≥50 years, Black Sub-Saharan African patients, and being on an integrase strand transfer inhibitor-based regimen were associated with being hospitalized. ICU admission and mechanical ventilation was required for 15% and 10% of all patients respectively. Overall, 9% of patients died while 78 (77%) patients made a full recovery. HIV patients with COVID-19 experienced a high degree of hospitalization despite having elevated CD4[SUP]+[/SUP] cell counts and a high rate of virologic suppression. Matched case-control studies are warranted to measure the impact that HIV may have on patients with COVID-19. This article is protected by copyright. All rights reserved.
Keywords: Belgium; COVID-19; clinical characteristics; outcomes; people living with HIV.