tetano
Editor, Senior Moderator
J Med Virol
. 2025 Feb;97(2):e70207.
doi: 10.1002/jmv.70207. Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study
Shuxia Wang[SUP] 1 [/SUP], Jin Sun[SUP] 1 2 [/SUP], Yazhuo Hu[SUP] 3 [/SUP], Wei Zhang[SUP] 4 [/SUP], Bangguo Qin[SUP] 2 [/SUP], Man Li[SUP] 1 [/SUP], Nan Zhang[SUP] 1 2 [/SUP], Shengshu Wang[SUP] 3 [/SUP], Tingyu Zhou[SUP] 5 [/SUP], Miao Liu[SUP] 6 [/SUP], Cong Ma[SUP] 7 [/SUP], Xinli Deng[SUP] 8 [/SUP], Yongyi Bai[SUP] 9 [/SUP], Geping Qu[SUP] 10 [/SUP], Lin Liu[SUP] 10 [/SUP], Hui Shi[SUP] 11 [/SUP], Bo Zhou[SUP] 12 [/SUP], Ke Li[SUP] 12 [/SUP], Bo Yang[SUP] 13 [/SUP], Suxia Li[SUP] 13 [/SUP], Fan Wang[SUP] 9 [/SUP], Jinling Ma[SUP] 9 [/SUP], Lu Zhang[SUP] 9 [/SUP], Yajuan Wang[SUP] 10 [/SUP], Li An[SUP] 10 [/SUP], Wenhui Liu[SUP] 11 [/SUP], Qing Chang[SUP] 11 [/SUP], Ru Zhang[SUP] 11 [/SUP], Xi Yin[SUP] 12 [/SUP], Yang Yang[SUP] 12 [/SUP], Qiangguo Ao[SUP] 14 [/SUP], Qiang Ma[SUP] 14 [/SUP], Shuangtong Yan[SUP] 15 [/SUP], Haili Huang[SUP] 16 [/SUP], Peng Song[SUP] 16 [/SUP], Shu Zhao[SUP] 16 [/SUP], Linggen Gao[SUP] 17 [/SUP], Wenning Lu[SUP] 17 [/SUP], Lining Xu[SUP] 17 [/SUP], Li Lei[SUP] 7 [/SUP], Keyu Wang[SUP] 8 [/SUP], Qing Song[SUP] 18 [/SUP], Zhijian Zhang[SUP] 10 [/SUP], Xiangqun Fang[SUP] 10 [/SUP], Yao He[SUP] 3 [/SUP], Qi Zhang[SUP] 19 [/SUP], Jianjun Jia[SUP] 3 [/SUP], Ping Zhu[SUP] 1 [/SUP]
Affiliations
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023. During this time, epidemiological, demographic, laboratory, and outcome data were analyzed descriptively. Proteomic sequencing was performed on super-elderly patients who died from COVID-19 at different stages of the disease. A total of 352 elderly COVID-19 patients, with a mean age of 89.84 ± 8.54 years, were included in this study. During a median follow-up period of 98 days, 79 patients died. Deceased patients were older and more likely to have cardiovascular and cerebrovascular diseases, with a lower prevalence of lipid-lowering therapy. The number of deaths in the acute and post-acute phases were 34 and 45, respectively. Proteomics data suggest that the immune systems of patients who died in the acute phase underwent a more rapid and severe onslaught. Patients in the post-acute phase showed higher levels of viral genome replication and a more robust immune response. However, the over-activation of the immune system led to systemic organ dysfunction. Effective management of comorbidities may improve the prognosis of COVID-19 in super-elderly patients. The continuous replication of the SARS-CoV-2 virus and its subsequent impact on the immune system are critical determinants of survival time in this demographic.
Keywords: COVID‐19; descriptive study; proteomics; super‐elderly.
. 2025 Feb;97(2):e70207.
doi: 10.1002/jmv.70207. Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study
Shuxia Wang[SUP] 1 [/SUP], Jin Sun[SUP] 1 2 [/SUP], Yazhuo Hu[SUP] 3 [/SUP], Wei Zhang[SUP] 4 [/SUP], Bangguo Qin[SUP] 2 [/SUP], Man Li[SUP] 1 [/SUP], Nan Zhang[SUP] 1 2 [/SUP], Shengshu Wang[SUP] 3 [/SUP], Tingyu Zhou[SUP] 5 [/SUP], Miao Liu[SUP] 6 [/SUP], Cong Ma[SUP] 7 [/SUP], Xinli Deng[SUP] 8 [/SUP], Yongyi Bai[SUP] 9 [/SUP], Geping Qu[SUP] 10 [/SUP], Lin Liu[SUP] 10 [/SUP], Hui Shi[SUP] 11 [/SUP], Bo Zhou[SUP] 12 [/SUP], Ke Li[SUP] 12 [/SUP], Bo Yang[SUP] 13 [/SUP], Suxia Li[SUP] 13 [/SUP], Fan Wang[SUP] 9 [/SUP], Jinling Ma[SUP] 9 [/SUP], Lu Zhang[SUP] 9 [/SUP], Yajuan Wang[SUP] 10 [/SUP], Li An[SUP] 10 [/SUP], Wenhui Liu[SUP] 11 [/SUP], Qing Chang[SUP] 11 [/SUP], Ru Zhang[SUP] 11 [/SUP], Xi Yin[SUP] 12 [/SUP], Yang Yang[SUP] 12 [/SUP], Qiangguo Ao[SUP] 14 [/SUP], Qiang Ma[SUP] 14 [/SUP], Shuangtong Yan[SUP] 15 [/SUP], Haili Huang[SUP] 16 [/SUP], Peng Song[SUP] 16 [/SUP], Shu Zhao[SUP] 16 [/SUP], Linggen Gao[SUP] 17 [/SUP], Wenning Lu[SUP] 17 [/SUP], Lining Xu[SUP] 17 [/SUP], Li Lei[SUP] 7 [/SUP], Keyu Wang[SUP] 8 [/SUP], Qing Song[SUP] 18 [/SUP], Zhijian Zhang[SUP] 10 [/SUP], Xiangqun Fang[SUP] 10 [/SUP], Yao He[SUP] 3 [/SUP], Qi Zhang[SUP] 19 [/SUP], Jianjun Jia[SUP] 3 [/SUP], Ping Zhu[SUP] 1 [/SUP]
Affiliations
- PMID: 39921383
- DOI: 10.1002/jmv.70207
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023. During this time, epidemiological, demographic, laboratory, and outcome data were analyzed descriptively. Proteomic sequencing was performed on super-elderly patients who died from COVID-19 at different stages of the disease. A total of 352 elderly COVID-19 patients, with a mean age of 89.84 ± 8.54 years, were included in this study. During a median follow-up period of 98 days, 79 patients died. Deceased patients were older and more likely to have cardiovascular and cerebrovascular diseases, with a lower prevalence of lipid-lowering therapy. The number of deaths in the acute and post-acute phases were 34 and 45, respectively. Proteomics data suggest that the immune systems of patients who died in the acute phase underwent a more rapid and severe onslaught. Patients in the post-acute phase showed higher levels of viral genome replication and a more robust immune response. However, the over-activation of the immune system led to systemic organ dysfunction. Effective management of comorbidities may improve the prognosis of COVID-19 in super-elderly patients. The continuous replication of the SARS-CoV-2 virus and its subsequent impact on the immune system are critical determinants of survival time in this demographic.
Keywords: COVID‐19; descriptive study; proteomics; super‐elderly.