tetano
Editor, Senior Moderator
J Med Virol
. 2024 Jun;96(6):e29722.
doi: 10.1002/jmv.29722. Association between influenza vaccination and one-year all-cause and cardiovascular mortality risk: A self-controlled case series and matched case-control study
Yuan Ma[SUP] 1 2 [/SUP], Wei Li[SUP] 3 [/SUP], Juan Li[SUP] 2 [/SUP], Jie Qian[SUP] 1 2 [/SUP], Mingyue Jiang[SUP] 1 2 [/SUP], Yanxia Sun[SUP] 1 2 [/SUP], Yue Ma[SUP] 4 [/SUP], Weizhong Yang[SUP] 1 2 [/SUP], Luzhao Feng[SUP] 1 5 6 [/SUP]
Affiliations
Debates surrounding the efficacy of influenza vaccination for survival benefits persist, and there is a lack of data regarding its duration of protection. A self-controlled case series (SCCS) and a 1:4 matched case-control study were conducted using the National Health Interview Survey (NHIS) and public-use mortality data from 2005 to 2018 in the United States. The SCCS study identified participants who received influenza vaccination within 12 months before the survey and subsequently died within 1 year of postvaccination. The matched case-control study paired participants who died during the influenza season at the time of survey with four survivors. Among 1167 participants in the SCCS study, there was a 46% reduction in all-cause mortality and a 43% reduction in cardiovascular mortality within 29-196 days of postvaccination. The greatest protection was observed during days 29-56 (all-cause mortality: RI: 0.19; 95% CI: 0.12-0.29; cardiovascular mortality: RI: 0.28; 95% CI: 0.14-0.56). Among 626 cases and 2504 controls included in the matched case-control study, influenza vaccination was associated with a reduction in all-cause mortality (OR: 0.74, 95% CI: 0.60-0.92) and cardiovascular mortality (OR: 0.64, 95% CI: 0.44-0.93) during the influenza season. This study highlights the importance of influenza vaccination in reducing the risks of all-cause and cardiovascular mortality, with effects lasting for approximately 6 months.
Keywords: all‐cause mortality; cardiovascular mortality; influenza; protective effect; vaccination.
. 2024 Jun;96(6):e29722.
doi: 10.1002/jmv.29722. Association between influenza vaccination and one-year all-cause and cardiovascular mortality risk: A self-controlled case series and matched case-control study
Yuan Ma[SUP] 1 2 [/SUP], Wei Li[SUP] 3 [/SUP], Juan Li[SUP] 2 [/SUP], Jie Qian[SUP] 1 2 [/SUP], Mingyue Jiang[SUP] 1 2 [/SUP], Yanxia Sun[SUP] 1 2 [/SUP], Yue Ma[SUP] 4 [/SUP], Weizhong Yang[SUP] 1 2 [/SUP], Luzhao Feng[SUP] 1 5 6 [/SUP]
Affiliations
- PMID: 38837255
- DOI: 10.1002/jmv.29722
Debates surrounding the efficacy of influenza vaccination for survival benefits persist, and there is a lack of data regarding its duration of protection. A self-controlled case series (SCCS) and a 1:4 matched case-control study were conducted using the National Health Interview Survey (NHIS) and public-use mortality data from 2005 to 2018 in the United States. The SCCS study identified participants who received influenza vaccination within 12 months before the survey and subsequently died within 1 year of postvaccination. The matched case-control study paired participants who died during the influenza season at the time of survey with four survivors. Among 1167 participants in the SCCS study, there was a 46% reduction in all-cause mortality and a 43% reduction in cardiovascular mortality within 29-196 days of postvaccination. The greatest protection was observed during days 29-56 (all-cause mortality: RI: 0.19; 95% CI: 0.12-0.29; cardiovascular mortality: RI: 0.28; 95% CI: 0.14-0.56). Among 626 cases and 2504 controls included in the matched case-control study, influenza vaccination was associated with a reduction in all-cause mortality (OR: 0.74, 95% CI: 0.60-0.92) and cardiovascular mortality (OR: 0.64, 95% CI: 0.44-0.93) during the influenza season. This study highlights the importance of influenza vaccination in reducing the risks of all-cause and cardiovascular mortality, with effects lasting for approximately 6 months.
Keywords: all‐cause mortality; cardiovascular mortality; influenza; protective effect; vaccination.