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J Med Virol Amplification of Human β-Glucoronidase Gene for Appraising the Accuracy of Negative SARS-CoV-2 RT-PCR Results in Upper Respiratory Tract

tetano

Editor, Senior Moderator
J Med Virol


. 2020 Jun 2.
doi: 10.1002/jmv.26112. Online ahead of print.
Amplification of Human β-Glucoronidase Gene for Appraising the Accuracy of Negative SARS-CoV-2 RT-PCR Results in Upper Respiratory Tract Specimens


Eliseo Albert[SUP] 1 [/SUP], Blanca Ferrer[SUP] 2 [/SUP], Ignacio Torres[SUP] 1 [/SUP], Alicia Serrano[SUP] 2 [/SUP], Mar?a Jes?s Alcaraz[SUP] 1 [/SUP], Javier Buesa[SUP] 1 3 [/SUP], Carlos Solano[SUP] 2 4 [/SUP], Javier Colomina[SUP] 1 [/SUP], Felipe Bueno[SUP] 1 [/SUP], Dixie Huntley[SUP] 1 [/SUP], Beatriz Olea[SUP] 1 [/SUP], Arantxa Valdivia[SUP] 1 [/SUP], David Navarro[SUP] 1 3 [/SUP]



Affiliations

Abstract

Real-time reverse transcription polymerase-chain reaction (RT-PCR) is the mainstay of Covid-19 diagnosis.[SUP]1[/SUP] Up to 30% of patients clinically suspected of Covid-19 may have initial or repeat RT-PCR negative results prior to positive test conversion, most notably when upper respiratory tract (URT) specimens are processed.[SUP]2-7[/SUP] This article is protected by copyright. All rights reserved.

Keywords: Epidemiology; Pandemics; Pathogenesis; Respiratory tract; SARS coronavirus; Virus classification.
 
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