tetano
Editor, Senior Moderator
J Med Virol. 2020 Feb 27. doi: 10.1002/jmv.25729. [Epub ahead of print] [h=1]A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus-A Possible Reference for Coronavirus Disease-19 Treatment Option.[/h]
Yao TT[SUP]1[/SUP], Qian JD[SUP]1[/SUP], Zhu WY[SUP]1[/SUP], Wang Y[SUP]1[/SUP], Wang GQ[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus disease-19 (COVID-19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVID-19. However, there are agents that were used during the SARS and MERS epidemics. We could learn from SARS and MERS. Lopinavir (LPV) is an effective agent that inhibits the protease activity of coronavirus. In this review, we discuss the literature on the efficacy of LPV in vitro and in vivo, especially in patients with SARS and MERS, so that we might clarify the potential for the use of LPV in patients with COVID-19. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] COVID-19; Coronavirus; Lopinavir; MERS; SARS
PMID: 32104907 DOI: 10.1002/jmv.25729
Yao TT[SUP]1[/SUP], Qian JD[SUP]1[/SUP], Zhu WY[SUP]1[/SUP], Wang Y[SUP]1[/SUP], Wang GQ[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus disease-19 (COVID-19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVID-19. However, there are agents that were used during the SARS and MERS epidemics. We could learn from SARS and MERS. Lopinavir (LPV) is an effective agent that inhibits the protease activity of coronavirus. In this review, we discuss the literature on the efficacy of LPV in vitro and in vivo, especially in patients with SARS and MERS, so that we might clarify the potential for the use of LPV in patients with COVID-19. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] COVID-19; Coronavirus; Lopinavir; MERS; SARS
PMID: 32104907 DOI: 10.1002/jmv.25729