tetano
Editor, Senior Moderator
J Med Virol
. 2023 May;95(5):e28776.
doi: 10.1002/jmv.28776. A comprehensive overview on the transmission, pathogenesis, diagnosis, treatment, and prevention of SARS-CoV-2
Yiting Zhang[SUP] 1 [/SUP], Setrice Patricia Clarke[SUP] 2 [/SUP], Huanwu Wu[SUP] 1 [/SUP], Wenli Li[SUP] 1 [/SUP], Chang Zhou[SUP] 1 [/SUP], Kang Lin[SUP] 3 [/SUP], Jiawen Wang[SUP] 4 [/SUP], Jinzhi Wang[SUP] 5 [/SUP], Ying Liang[SUP] 6 [/SUP], Xin Wang[SUP] 7 [/SUP], Linding Wang[SUP] 1 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a single positive-strand RNA virus that is responsible for the current pandemic that the world has been facing since 2019. The primary route of transmission of SARS-CoV-2 is through respiratory tract transmission. However, other transmission routes such as fecal-oral, vertical transmission, and aerosol-eye also exist. In addition, it has been found that the pathogenesis of this virus involves the binding of the virus's S protein to its host cell surface receptor angiotensin-converting enzyme 2, which results in the subsequent membrane fusion that is required for SARS-CoV-2 to replicate and complete its entire life. The clinical symptoms of patients infected with SARS-CoV-2 can range from asymptomatic to severe. The most common symptoms seen include fever, dry cough, and fatigue. Once these symptoms are observed, a nucleic acid test is done using reverse transcription-polymerase chain reaction. This currently serves as the main confirmatory tool for COVID-19. Despite the fact that no cure has been found for SARS-CoV-2, prevention methods such as vaccines, specific facial mask, and social distancing have proven to be quite effective. It is imperative to have a complete understanding of the transmission and pathogenesis of this virus. To effectively develop new drugs as well as diagnostic tools, more knowledge about this virus would be needed.
Keywords: COVID-19; SARS-CoV-2; diagnosis; pathogenesis; prevention; transmission.
. 2023 May;95(5):e28776.
doi: 10.1002/jmv.28776. A comprehensive overview on the transmission, pathogenesis, diagnosis, treatment, and prevention of SARS-CoV-2
Yiting Zhang[SUP] 1 [/SUP], Setrice Patricia Clarke[SUP] 2 [/SUP], Huanwu Wu[SUP] 1 [/SUP], Wenli Li[SUP] 1 [/SUP], Chang Zhou[SUP] 1 [/SUP], Kang Lin[SUP] 3 [/SUP], Jiawen Wang[SUP] 4 [/SUP], Jinzhi Wang[SUP] 5 [/SUP], Ying Liang[SUP] 6 [/SUP], Xin Wang[SUP] 7 [/SUP], Linding Wang[SUP] 1 [/SUP]
Affiliations
- PMID: 37212261
- DOI: 10.1002/jmv.28776
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a single positive-strand RNA virus that is responsible for the current pandemic that the world has been facing since 2019. The primary route of transmission of SARS-CoV-2 is through respiratory tract transmission. However, other transmission routes such as fecal-oral, vertical transmission, and aerosol-eye also exist. In addition, it has been found that the pathogenesis of this virus involves the binding of the virus's S protein to its host cell surface receptor angiotensin-converting enzyme 2, which results in the subsequent membrane fusion that is required for SARS-CoV-2 to replicate and complete its entire life. The clinical symptoms of patients infected with SARS-CoV-2 can range from asymptomatic to severe. The most common symptoms seen include fever, dry cough, and fatigue. Once these symptoms are observed, a nucleic acid test is done using reverse transcription-polymerase chain reaction. This currently serves as the main confirmatory tool for COVID-19. Despite the fact that no cure has been found for SARS-CoV-2, prevention methods such as vaccines, specific facial mask, and social distancing have proven to be quite effective. It is imperative to have a complete understanding of the transmission and pathogenesis of this virus. To effectively develop new drugs as well as diagnostic tools, more knowledge about this virus would be needed.
Keywords: COVID-19; SARS-CoV-2; diagnosis; pathogenesis; prevention; transmission.