tetano
Editor, Senior Moderator
J Med Cases
. 2022 Feb;13(2):89-93.
doi: 10.14740/jmc3880. Epub 2022 Feb 16.
Toxic Epidermal Necrolysis-Like Lupus Erythematous Presentation Following SARS-CoV-2 Infection
Ana Luisa Nunes[SUP] 1 [/SUP], Leonor Simoes[SUP] 2 [/SUP], Carolina Figueiredo[SUP] 3 [/SUP], Ruben Carvalho[SUP] 4 [/SUP], Jandira Lima[SUP] 1 [/SUP], Rui M Santos[SUP] 1 [/SUP]
Affiliations
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Infectious agents have been implicated in the pathogenesis of SLE. The emergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a pro-inflammatory cytokine storm and has been linked to autoimmune phenomena, which can lead to the onset of autoimmune diseases. We report the case of a 70-year-old patient who developed a toxic epidermal necrolysis (TEN)-like subacute cutaneous lupus (SCL) as a severe presentation of SLE, 1 month after SARS-CoV-2 infection. After excluding other causes of SLE, treatment was initiated with a successful outcome.
Keywords: COVID-19; SARS-CoV-2; Subacute cutaneous lupus; Systemic lupus erythematous; Toxic epidermal necrolysis.
. 2022 Feb;13(2):89-93.
doi: 10.14740/jmc3880. Epub 2022 Feb 16.
Toxic Epidermal Necrolysis-Like Lupus Erythematous Presentation Following SARS-CoV-2 Infection
Ana Luisa Nunes[SUP] 1 [/SUP], Leonor Simoes[SUP] 2 [/SUP], Carolina Figueiredo[SUP] 3 [/SUP], Ruben Carvalho[SUP] 4 [/SUP], Jandira Lima[SUP] 1 [/SUP], Rui M Santos[SUP] 1 [/SUP]
Affiliations
- PMID: 35317091
- PMCID: PMC8913004
- DOI: 10.14740/jmc3880
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Infectious agents have been implicated in the pathogenesis of SLE. The emergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a pro-inflammatory cytokine storm and has been linked to autoimmune phenomena, which can lead to the onset of autoimmune diseases. We report the case of a 70-year-old patient who developed a toxic epidermal necrolysis (TEN)-like subacute cutaneous lupus (SCL) as a severe presentation of SLE, 1 month after SARS-CoV-2 infection. After excluding other causes of SLE, treatment was initiated with a successful outcome.
Keywords: COVID-19; SARS-CoV-2; Subacute cutaneous lupus; Systemic lupus erythematous; Toxic epidermal necrolysis.