tetano
Editor, Senior Moderator
J Med Cases
. 2020 Dec;11(12):375-378.
doi: 10.14740/jmc3584. Epub 2020 Oct 21.
Multisystemic Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection: A Case Series Report in a Pediatric Center in Mexico
Miguel Garcia-Dominguez[SUP] 1 [/SUP], Yanin Angeles-Meneses[SUP] 2 [/SUP], Angelica Lares-Payan[SUP] 2 [/SUP], Carlos Alberto Velazquez-Rios[SUP] 3 [/SUP], Edgardo Tostado Morales[SUP] 4 [/SUP], Giordano Perez-Gaxiola[SUP] 5 [/SUP]
Affiliations
Abstract
We report four cases of patients with multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, of which three patients presented characteristics of Kawasaki disease (KD). All presented fever of more than 3 days, and gastrointestinal involvement, significant increase in C-reactive protein (CRP), polymorphonuclear cells, procalcitonin, D-dimer, fibrinogen and troponin, lymphopenia and hypoalbuminemia. Myocardial involvement was observed in two patients. All were treated with fluids resuscitation and vasoactive therapy, 75% received intravenous immunoglobulin (IVIG) and systemic steroids. Two patients developed a transient acute kidney injury, one patient presented as acute appendicitis and developed a bilateral pleural effusion. One patient required a second dose of IVIG and boluses of methylprednisolone. None required mechanical ventilation and there were no deaths.
Keywords: COVID-19; Kawasaki disease; Kawasaki disease shock syndrome; Multisystem inflammatory syndrome in children; Myocarditis; SARS-CoV-2.
. 2020 Dec;11(12):375-378.
doi: 10.14740/jmc3584. Epub 2020 Oct 21.
Multisystemic Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection: A Case Series Report in a Pediatric Center in Mexico
Miguel Garcia-Dominguez[SUP] 1 [/SUP], Yanin Angeles-Meneses[SUP] 2 [/SUP], Angelica Lares-Payan[SUP] 2 [/SUP], Carlos Alberto Velazquez-Rios[SUP] 3 [/SUP], Edgardo Tostado Morales[SUP] 4 [/SUP], Giordano Perez-Gaxiola[SUP] 5 [/SUP]
Affiliations
- PMID: 33984083
- PMCID: PMC8040441
- DOI: 10.14740/jmc3584
Abstract
We report four cases of patients with multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, of which three patients presented characteristics of Kawasaki disease (KD). All presented fever of more than 3 days, and gastrointestinal involvement, significant increase in C-reactive protein (CRP), polymorphonuclear cells, procalcitonin, D-dimer, fibrinogen and troponin, lymphopenia and hypoalbuminemia. Myocardial involvement was observed in two patients. All were treated with fluids resuscitation and vasoactive therapy, 75% received intravenous immunoglobulin (IVIG) and systemic steroids. Two patients developed a transient acute kidney injury, one patient presented as acute appendicitis and developed a bilateral pleural effusion. One patient required a second dose of IVIG and boluses of methylprednisolone. None required mechanical ventilation and there were no deaths.
Keywords: COVID-19; Kawasaki disease; Kawasaki disease shock syndrome; Multisystem inflammatory syndrome in children; Myocarditis; SARS-CoV-2.