tetano
Editor, Senior Moderator
J Med Cases
. 2025 Jul 19;16(7):254-258.
doi: 10.14740/jmc5129. eCollection 2025 Jul. Influenza A H1N1 Triggering Complement-Mediated Hemolytic Uremic Syndrome
Sathwik Madireddy[SUP] 1 [/SUP], MacKenzie Adams[SUP] 1 [/SUP], Boris Martinez Recinos[SUP] 1 2 [/SUP]
Affiliations
Complement-mediated hemolytic uremic syndrome (CM-HUS) is a condition characterized by hemolytic anemia, thrombocytopenia, and renal impairment, typically associated with a chronic dysregulation of the complement system. Few adult cases of CM-HUS triggered by influenza infection have been described. Here we present a case of a 56-year-old female with multiple myeloma receiving cancer treatment who presented with Influenza A H1N1-associated CM-HUS. She was treated with anti-complement therapy and at her 1-month follow-up had complete resolution of renal dysfunction and hemolytic anemia. This case highlights influenza infection as a trigger for CM-HUS in an immunocompromised adult and the role of anti-complement therapies.
Keywords: Atypical HUS; CM-HUS; Influenza.
. 2025 Jul 19;16(7):254-258.
doi: 10.14740/jmc5129. eCollection 2025 Jul. Influenza A H1N1 Triggering Complement-Mediated Hemolytic Uremic Syndrome
Sathwik Madireddy[SUP] 1 [/SUP], MacKenzie Adams[SUP] 1 [/SUP], Boris Martinez Recinos[SUP] 1 2 [/SUP]
Affiliations
- PMID: 40727115
- PMCID: PMC12292013
- DOI: 10.14740/jmc5129
Complement-mediated hemolytic uremic syndrome (CM-HUS) is a condition characterized by hemolytic anemia, thrombocytopenia, and renal impairment, typically associated with a chronic dysregulation of the complement system. Few adult cases of CM-HUS triggered by influenza infection have been described. Here we present a case of a 56-year-old female with multiple myeloma receiving cancer treatment who presented with Influenza A H1N1-associated CM-HUS. She was treated with anti-complement therapy and at her 1-month follow-up had complete resolution of renal dysfunction and hemolytic anemia. This case highlights influenza infection as a trigger for CM-HUS in an immunocompromised adult and the role of anti-complement therapies.
Keywords: Atypical HUS; CM-HUS; Influenza.