tetano
Editor, Senior Moderator
J Med Case Rep
. 2022 Dec 27;16(1):488.
doi: 10.1186/s13256-022-03680-5.
Necrotizing autoimmune myositis following coronavirus disease 2019 infection: a case report
Maryam Loghman[SUP] 1 [/SUP], Ehsan Rahmanian[SUP] 2 [/SUP], Majid Alikhani[SUP] 1 [/SUP], Hiva Saffar[SUP] 3 [/SUP], Sara Beikmohamadi Hezaveh[SUP] 4 [/SUP], Mohammad Nekooeian[SUP] 5 [/SUP], Reza Shahriarirad[SUP] 6 7 [/SUP], Seyedeh Tahereh Faezi[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 may be associated with late-onset necrotizing myositis, mimicking autoimmune inflammatory myositis; however, the exact underlying pathogenesis of severe acute respiratory syndrome coronavirus 2-induced myositis is still unclear.
Case presentation: Herein, we report a rare case of necrotizing autoimmune myositis in a 67-year-old middle eastern male following coronavirus disease 2019 infection, who presented with muscle weakness. The patient had positive anti-NXP2. The diagnosis of necrotizing autoimmune myositis was made according to muscle weakness, increased liver enzymes, electromyography and nerve conduction velocity results, and muscle biopsy. The patient underwent a full malignancy evaluation, which was unremarkable, and was discharged in relatively well condition with a daily dose of 1 mg/kg prednisolone and azathioprine 150 mg (2 mg/kg).
Conclusion: Our report highlights the already known possible protracted sequence of coronavirus disease 2019 infection and the potential for delayed-onset necrotizing myositis.
Keywords: COVID-19; Case report; Muscle weakness; Myalgia; Myositis; SARS-CoV-2.
. 2022 Dec 27;16(1):488.
doi: 10.1186/s13256-022-03680-5.
Necrotizing autoimmune myositis following coronavirus disease 2019 infection: a case report
Maryam Loghman[SUP] 1 [/SUP], Ehsan Rahmanian[SUP] 2 [/SUP], Majid Alikhani[SUP] 1 [/SUP], Hiva Saffar[SUP] 3 [/SUP], Sara Beikmohamadi Hezaveh[SUP] 4 [/SUP], Mohammad Nekooeian[SUP] 5 [/SUP], Reza Shahriarirad[SUP] 6 7 [/SUP], Seyedeh Tahereh Faezi[SUP] 1 [/SUP]
Affiliations
- PMID: 36575546
- DOI: 10.1186/s13256-022-03680-5
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 may be associated with late-onset necrotizing myositis, mimicking autoimmune inflammatory myositis; however, the exact underlying pathogenesis of severe acute respiratory syndrome coronavirus 2-induced myositis is still unclear.
Case presentation: Herein, we report a rare case of necrotizing autoimmune myositis in a 67-year-old middle eastern male following coronavirus disease 2019 infection, who presented with muscle weakness. The patient had positive anti-NXP2. The diagnosis of necrotizing autoimmune myositis was made according to muscle weakness, increased liver enzymes, electromyography and nerve conduction velocity results, and muscle biopsy. The patient underwent a full malignancy evaluation, which was unremarkable, and was discharged in relatively well condition with a daily dose of 1 mg/kg prednisolone and azathioprine 150 mg (2 mg/kg).
Conclusion: Our report highlights the already known possible protracted sequence of coronavirus disease 2019 infection and the potential for delayed-onset necrotizing myositis.
Keywords: COVID-19; Case report; Muscle weakness; Myalgia; Myositis; SARS-CoV-2.