tetano
Editor, Senior Moderator
J Med Case Rep
. 2022 Mar 14;16(1):106.
doi: 10.1186/s13256-022-03322-w.
Glucose-6-phosphate dehydrogenase deficiency presenting with rhabdomyolysis in a patient with coronavirus disease 2019 pneumonia: a case report
Regina Yu[SUP] 1 [/SUP], Chien-Rong Chen[SUP] 2 [/SUP], Darci Evans[SUP] 1 [/SUP], Xin Qing[SUP] 3 [/SUP], Moran Gotesman[SUP] 4 [/SUP], Gangadarshni Chandramohan[SUP] 5 [/SUP], Thomas Kallay[SUP] 1 [/SUP], Henry J Lin[SUP] 6 [/SUP], Tiffany P Pedigo[SUP] 7 [/SUP]
Affiliations
Abstract
Background: Glucose-6-phosphate dehydrogenase deficiency is a rarely recognized predisposing factor for rhabdomyolysis. Rhabdomyolysis with coronavirus disease 2019 has been increasingly seen during the pandemic. We report the uncommon occurrence of coronavirus disease 2019 pneumonia, severe rhabdomyolysis, and acute renal failure in the setting of glucose-6-phosphate dehydrogenase deficiency.
Case presentation: A 19-year-old African American male presented with myalgias, diaphoresis, and dark urine. Testing for severe acute respiratory syndrome coronavirus 2 was positive. He had severe rhabdomyolysis with creatine kinase levels up to 346,695 U/L. He was oliguric and eventually required hemodialysis. Progressive hypoxemia, methemoglobinemia, and hemolytic anemia occurred following one dose of rasburicase for hyperuricemia. Glucose-6-phosphate dehydrogenase deficiency was diagnosed. Full recovery followed a single volume exchange transfusion and simple packed red blood cell transfusions.
Conclusions: Glucose-6-phosphate dehydrogenase deficiency may predispose individuals to rhabdomyolysis due to severe acute respiratory syndrome coronavirus 2, presumably due to altered host responses to viral oxidative stress. Early screening for glucose-6-phosphate dehydrogenase deficiency can be useful for management of patients with rhabdomyolysis.
Keywords: Acute kidney injury; COVID-19; Case report; G6PD deficiency; Methemoglobinemia; Rhabdomyolysis; SARS-CoV-2.
. 2022 Mar 14;16(1):106.
doi: 10.1186/s13256-022-03322-w.
Glucose-6-phosphate dehydrogenase deficiency presenting with rhabdomyolysis in a patient with coronavirus disease 2019 pneumonia: a case report
Regina Yu[SUP] 1 [/SUP], Chien-Rong Chen[SUP] 2 [/SUP], Darci Evans[SUP] 1 [/SUP], Xin Qing[SUP] 3 [/SUP], Moran Gotesman[SUP] 4 [/SUP], Gangadarshni Chandramohan[SUP] 5 [/SUP], Thomas Kallay[SUP] 1 [/SUP], Henry J Lin[SUP] 6 [/SUP], Tiffany P Pedigo[SUP] 7 [/SUP]
Affiliations
- PMID: 35287717
- DOI: 10.1186/s13256-022-03322-w
Abstract
Background: Glucose-6-phosphate dehydrogenase deficiency is a rarely recognized predisposing factor for rhabdomyolysis. Rhabdomyolysis with coronavirus disease 2019 has been increasingly seen during the pandemic. We report the uncommon occurrence of coronavirus disease 2019 pneumonia, severe rhabdomyolysis, and acute renal failure in the setting of glucose-6-phosphate dehydrogenase deficiency.
Case presentation: A 19-year-old African American male presented with myalgias, diaphoresis, and dark urine. Testing for severe acute respiratory syndrome coronavirus 2 was positive. He had severe rhabdomyolysis with creatine kinase levels up to 346,695 U/L. He was oliguric and eventually required hemodialysis. Progressive hypoxemia, methemoglobinemia, and hemolytic anemia occurred following one dose of rasburicase for hyperuricemia. Glucose-6-phosphate dehydrogenase deficiency was diagnosed. Full recovery followed a single volume exchange transfusion and simple packed red blood cell transfusions.
Conclusions: Glucose-6-phosphate dehydrogenase deficiency may predispose individuals to rhabdomyolysis due to severe acute respiratory syndrome coronavirus 2, presumably due to altered host responses to viral oxidative stress. Early screening for glucose-6-phosphate dehydrogenase deficiency can be useful for management of patients with rhabdomyolysis.
Keywords: Acute kidney injury; COVID-19; Case report; G6PD deficiency; Methemoglobinemia; Rhabdomyolysis; SARS-CoV-2.