tetano
Editor, Senior Moderator
J Med Case Rep
. 2025 May 7;19(1):213.
doi: 10.1186/s13256-025-05254-7. Chilblain-like lesion associated with coronavirus disease 2019 vaccine in tropical country: a case report
Wasuchon Chaichan[SUP] 1 [/SUP], Mati Chuamanochan[SUP] 1 [/SUP], Pongsak Mahanupab[SUP] 2 [/SUP], Siri Chiewchanvit[SUP] 1 [/SUP], Napatra Tovanabutra[SUP] 3 [/SUP]
Affiliations
Background: Chilblains have emerged as a cutaneous manifestation following coronavirus disease 2019 vaccination. While there are many case reports on chilblain-like lesions, documentation from tropical countries remains limited. In this context, we report a case detailing chilblain-like lesions associated with coronavirus disease 2019 vaccination in Thailand.
Case presentation: A 35-year-old Thai female patient presented with several painful, red papules on the fingers and toes 9 days after receiving the mRNA-1273 vaccination. Skin biopsy was performed, and the results were consistent with chilblains. Laboratory workup revealed positive result for lupus anticoagulant. The rash completely resolved without any treatment but reappeared following the second vaccine dose.
Conclusion: Chilblain-like lesion following coronavirus disease 2019 vaccination is frequently observed in temperate countries, with few reports from tropical areas. The presence of lupus anticoagulant may contribute to the development of chilblains after coronavirus disease 2019 vaccination.
Keywords: COVID-19 vaccine; Case report; Chilblain-like lesion; Chilblains; Lupus anticoagulant.
. 2025 May 7;19(1):213.
doi: 10.1186/s13256-025-05254-7. Chilblain-like lesion associated with coronavirus disease 2019 vaccine in tropical country: a case report
Wasuchon Chaichan[SUP] 1 [/SUP], Mati Chuamanochan[SUP] 1 [/SUP], Pongsak Mahanupab[SUP] 2 [/SUP], Siri Chiewchanvit[SUP] 1 [/SUP], Napatra Tovanabutra[SUP] 3 [/SUP]
Affiliations
- PMID: 40336095
- DOI: 10.1186/s13256-025-05254-7
Background: Chilblains have emerged as a cutaneous manifestation following coronavirus disease 2019 vaccination. While there are many case reports on chilblain-like lesions, documentation from tropical countries remains limited. In this context, we report a case detailing chilblain-like lesions associated with coronavirus disease 2019 vaccination in Thailand.
Case presentation: A 35-year-old Thai female patient presented with several painful, red papules on the fingers and toes 9 days after receiving the mRNA-1273 vaccination. Skin biopsy was performed, and the results were consistent with chilblains. Laboratory workup revealed positive result for lupus anticoagulant. The rash completely resolved without any treatment but reappeared following the second vaccine dose.
Conclusion: Chilblain-like lesion following coronavirus disease 2019 vaccination is frequently observed in temperate countries, with few reports from tropical areas. The presence of lupus anticoagulant may contribute to the development of chilblains after coronavirus disease 2019 vaccination.
Keywords: COVID-19 vaccine; Case report; Chilblain-like lesion; Chilblains; Lupus anticoagulant.