tetano
Editor, Senior Moderator
J Korean Med Sci
. 2023 Feb 27;38(8):e55.
doi: 10.3346/jkms.2023.38.e55.
The Risk Factors and Outcomes for Radiological Abnormalities in Early Convalescence of COVID-19 Patients Caused by the SARS-CoV-2 Omicron Variant: A Retrospective, Multicenter Follow-up Study
Hong Wang[SUP] #[/SUP][SUP] 1 [/SUP], Qingyuan Yang[SUP] #[/SUP][SUP] 2 [/SUP], Fangfei Li[SUP] #[/SUP][SUP] 1 [/SUP], Huiying Wang[SUP] 1 [/SUP], Jing Yu[SUP] 1 [/SUP], Xihong Ge[SUP] 1 [/SUP], Guangfeng Gao[SUP] 1 [/SUP], Shuang Xia[SUP] 1 [/SUP], Zhiheng Xing[SUP] 3 [/SUP], Wen Shen[SUP] 4 [/SUP]
Affiliations
Abstract
Background: The emergence of the severe acute respiratory syndrome coronavirus 2 omicron variant has been triggering the new wave of coronavirus disease 2019 (COVID-19) globally. However, the risk factors and outcomes for radiological abnormalities in the early convalescent stage (1 month after diagnosis) of omicron infected patients are still unknown.
Methods: Patients were retrospectively enrolled if they were admitted to the hospital due to COVID-19. The chest computed tomography (CT) images and clinical data obtained at baseline (at the time of the first CT image that showed abnormalities after diagnosis) and 1 month after diagnosis were longitudinally analyzed. Uni-/multi-variable logistic regression tests were performed to explore independent risk factors for radiological abnormalities at baseline and residual pulmonary abnormalities after 1 month.
Results: We assessed 316 COVID-19 patients, including 47% with radiological abnormalities at baseline and 23% with residual pulmonary abnormalities at 1-month follow-up. In a multivariate regression analysis, age ≥ 50 years, body mass index ≥ 23.87, days after vaccination ≥ 81 days, lymphocyte count ≤ 1.21 × 10[SUP]-9[/SUP]/L, interleukin-6 (IL-6) ≥ 10.05 pg/mL and IgG ≤ 14.140 S/CO were independent risk factors for CT abnormalities at baseline. The age ≥ 47 years, presence of interlobular septal thickening and IL-6 ≥ 5.85 pg/mL were the independent risk factors for residual pulmonary abnormalities at 1-month follow-up. For residual abnormalities group, the patients with less consolidations and more parenchymal bands at baseline could progress on CT score after 1 month. There were no significant changes in the number of involved lung lobes and total CT score during the early convalescent stage.
Conclusion: The higher IL-6 level was a common independent risk factor for CT abnormalities at baseline and residual pulmonary abnormalities at 1-month follow-up. There were no obvious radiographic changes during the early convalescent stage in patients with residual pulmonary abnormalities.
Keywords: COVID-19; CT Abnormalities; Convalescence; Follow-up; Omicron.
. 2023 Feb 27;38(8):e55.
doi: 10.3346/jkms.2023.38.e55.
The Risk Factors and Outcomes for Radiological Abnormalities in Early Convalescence of COVID-19 Patients Caused by the SARS-CoV-2 Omicron Variant: A Retrospective, Multicenter Follow-up Study
Hong Wang[SUP] #[/SUP][SUP] 1 [/SUP], Qingyuan Yang[SUP] #[/SUP][SUP] 2 [/SUP], Fangfei Li[SUP] #[/SUP][SUP] 1 [/SUP], Huiying Wang[SUP] 1 [/SUP], Jing Yu[SUP] 1 [/SUP], Xihong Ge[SUP] 1 [/SUP], Guangfeng Gao[SUP] 1 [/SUP], Shuang Xia[SUP] 1 [/SUP], Zhiheng Xing[SUP] 3 [/SUP], Wen Shen[SUP] 4 [/SUP]
Affiliations
- PMID: 36852851
- DOI: 10.3346/jkms.2023.38.e55
Abstract
Background: The emergence of the severe acute respiratory syndrome coronavirus 2 omicron variant has been triggering the new wave of coronavirus disease 2019 (COVID-19) globally. However, the risk factors and outcomes for radiological abnormalities in the early convalescent stage (1 month after diagnosis) of omicron infected patients are still unknown.
Methods: Patients were retrospectively enrolled if they were admitted to the hospital due to COVID-19. The chest computed tomography (CT) images and clinical data obtained at baseline (at the time of the first CT image that showed abnormalities after diagnosis) and 1 month after diagnosis were longitudinally analyzed. Uni-/multi-variable logistic regression tests were performed to explore independent risk factors for radiological abnormalities at baseline and residual pulmonary abnormalities after 1 month.
Results: We assessed 316 COVID-19 patients, including 47% with radiological abnormalities at baseline and 23% with residual pulmonary abnormalities at 1-month follow-up. In a multivariate regression analysis, age ≥ 50 years, body mass index ≥ 23.87, days after vaccination ≥ 81 days, lymphocyte count ≤ 1.21 × 10[SUP]-9[/SUP]/L, interleukin-6 (IL-6) ≥ 10.05 pg/mL and IgG ≤ 14.140 S/CO were independent risk factors for CT abnormalities at baseline. The age ≥ 47 years, presence of interlobular septal thickening and IL-6 ≥ 5.85 pg/mL were the independent risk factors for residual pulmonary abnormalities at 1-month follow-up. For residual abnormalities group, the patients with less consolidations and more parenchymal bands at baseline could progress on CT score after 1 month. There were no significant changes in the number of involved lung lobes and total CT score during the early convalescent stage.
Conclusion: The higher IL-6 level was a common independent risk factor for CT abnormalities at baseline and residual pulmonary abnormalities at 1-month follow-up. There were no obvious radiographic changes during the early convalescent stage in patients with residual pulmonary abnormalities.
Keywords: COVID-19; CT Abnormalities; Convalescence; Follow-up; Omicron.