tetano
Editor, Senior Moderator
J Korean Med Sci
. 2023 Feb 6;38(5):e22.
doi: 10.3346/jkms.2023.38.e22.
Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea
Seung Hwan Song[SUP] 1 [/SUP], Ku Yong Chung[SUP] 1 [/SUP], Yongho Jee[SUP] 2 [/SUP], Hae-Sun Chung[SUP] 3 [/SUP], Kina Kim[SUP] 4 [/SUP], Dohsik Minn[SUP] 4 [/SUP], Soo-Kyung Kim[SUP] 5 [/SUP]
Affiliations
Abstract
Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (≥ 100 U/mL) and neutralizing antibody responses (≥ 30%) were detected in 51/85 (60.0%) patients. When we divided the patients with the time from transplantation to vaccination (< 1, 1-2.4, 2.5-4.9, and ≥ 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7-52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine. A shorter time from transplantation to vaccination was a risk factor for a low antibody response.
Keywords: COVID-19; Kidney Transplantation; SARS-CoV-2; Vaccine.
. 2023 Feb 6;38(5):e22.
doi: 10.3346/jkms.2023.38.e22.
Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea
Seung Hwan Song[SUP] 1 [/SUP], Ku Yong Chung[SUP] 1 [/SUP], Yongho Jee[SUP] 2 [/SUP], Hae-Sun Chung[SUP] 3 [/SUP], Kina Kim[SUP] 4 [/SUP], Dohsik Minn[SUP] 4 [/SUP], Soo-Kyung Kim[SUP] 5 [/SUP]
Affiliations
- PMID: 36747360
- DOI: 10.3346/jkms.2023.38.e22
Abstract
Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (≥ 100 U/mL) and neutralizing antibody responses (≥ 30%) were detected in 51/85 (60.0%) patients. When we divided the patients with the time from transplantation to vaccination (< 1, 1-2.4, 2.5-4.9, and ≥ 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7-52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine. A shorter time from transplantation to vaccination was a risk factor for a low antibody response.
Keywords: COVID-19; Kidney Transplantation; SARS-CoV-2; Vaccine.