tetano
Editor, Senior Moderator
J Korean Med Sci
. 2022 Apr 18;37(15):e116.
doi: 10.3346/jkms.2022.37.e116.
Autoimmune Hepatitis Following Vaccination for SARS-CoV-2 in Korea: Coincidence or Autoimmunity?
Seong Hee Kang[SUP] 1 2 [/SUP], Moon Young Kim[SUP] 1 3 [/SUP], Mee Yon Cho[SUP] 4 [/SUP], Soon Koo Baik[SUP] 1 5 [/SUP]
Affiliations
Abstract
Autoimmune hepatitis (AIH) is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells, causing the liver to be inflamed. AIH is one of the manifestations of a coronavirus disease 2019 (COVID-19), as well as an adverse event occurring after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Few cases of AIH have been described after vaccination with two messenger RNA (mRNA)-based vaccines-BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-against SARS-CoV-2. Herein, we report a case of AIH occurring after Pfizer-BioNTech COVID-19 vaccine. A 27-year-old female presented with jaundice and hepatomegaly, appearing 14 days after receiving the second dose of Pfizer-BioNTech vaccine. Her laboratory results showed abnormal liver function with high total immunoglobulin G level. She was diagnosed with AIH with histologic finding and successfully treated with oral prednisolone. We report an AIH case after COVID-19 vaccination in Korea.
Keywords: Autoimmune Hepatitis; Coronavirus Disease 2019; Vaccine.
. 2022 Apr 18;37(15):e116.
doi: 10.3346/jkms.2022.37.e116.
Autoimmune Hepatitis Following Vaccination for SARS-CoV-2 in Korea: Coincidence or Autoimmunity?
Seong Hee Kang[SUP] 1 2 [/SUP], Moon Young Kim[SUP] 1 3 [/SUP], Mee Yon Cho[SUP] 4 [/SUP], Soon Koo Baik[SUP] 1 5 [/SUP]
Affiliations
- PMID: 35437965
- DOI: 10.3346/jkms.2022.37.e116
Abstract
Autoimmune hepatitis (AIH) is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells, causing the liver to be inflamed. AIH is one of the manifestations of a coronavirus disease 2019 (COVID-19), as well as an adverse event occurring after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Few cases of AIH have been described after vaccination with two messenger RNA (mRNA)-based vaccines-BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)-against SARS-CoV-2. Herein, we report a case of AIH occurring after Pfizer-BioNTech COVID-19 vaccine. A 27-year-old female presented with jaundice and hepatomegaly, appearing 14 days after receiving the second dose of Pfizer-BioNTech vaccine. Her laboratory results showed abnormal liver function with high total immunoglobulin G level. She was diagnosed with AIH with histologic finding and successfully treated with oral prednisolone. We report an AIH case after COVID-19 vaccination in Korea.
Keywords: Autoimmune Hepatitis; Coronavirus Disease 2019; Vaccine.