tetano
Editor, Senior Moderator
J Intern Med
. 2023 Apr 10.
doi: 10.1111/joim.13642. Online ahead of print.
Residual pulmonary infiltrates, symptoms and diffusion impairment at one-year after severe COVID-19 infection have different associated factors
Rosario Menéndez[SUP] 1 2 3 4 [/SUP], Raúl Méndez[SUP] 1 2 3 4 [/SUP], Ana Latorre[SUP] 1 2 [/SUP], Paula González-Jiménez[SUP] 1 2 4 [/SUP], Germán Peces-Barba[SUP] 5 [/SUP], María Molina[SUP] 6 [/SUP], Pedro Pablo España[SUP] 7 [/SUP], Estela García[SUP] 8 [/SUP], Angélica Consuegra-Vanegas[SUP] 9 [/SUP], Ana Pando-Sandoval[SUP] 10 [/SUP], Carolina Panadero[SUP] 11 [/SUP], Juan Marco Figueira-Gonçalves[SUP] 12 [/SUP], David De la Rosa[SUP] 13 [/SUP], Oriol Sibila[SUP] 14 [/SUP], María Dolores Martínez-Pitarch[SUP] 15 [/SUP], Nuria Toledo[SUP] 16 [/SUP], Pilar Cejudo[SUP] 17 [/SUP], Wanda Almonte-Batista[SUP] 18 [/SUP], Abigail Macías-Paredes[SUP] 19 [/SUP], Diana Badenes[SUP] 20 [/SUP], Eli Nancy Pérez-Rodas[SUP] 21 [/SUP], Javier Lázaro[SUP] 22 [/SUP], Sarai Quirós[SUP] 23 [/SUP], Rosa Cordovilla[SUP] 24 [/SUP], Irene Cano-Pumarega[SUP] 3 25 [/SUP], Antoni Torres[SUP] 14 [/SUP]
Affiliations
Abstract
Introduction: After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year follow-up. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (D[SUB]LCO[/SUB] ) at 1-year follow-up in patients from the Spanish Registry RECOVID.
Methods: RECOVID collected symptom and radiological and functional lung tests data on hospitalised patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits.
Results: Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae, and 31% had reduced D[SUB]LCO[/SUB] . Independently associated factors included female sex, asthma, and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO[SUB]2[/SUB] /FiO[SUB]2[/SUB] <450 or CURB65 ≥2. Reduced D[SUB]LCO[/SUB] was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO[SUB]2[/SUB] /FiO[SUB]2[/SUB] <450 and CURB-65 ≥2, and the requirement of respiratory support. At 12 months, a proportion of the asymptomatic patients showed reduced D[SUB]LCO[/SUB] (9.5%), radiological findings (25%), or both (11%).
Conclusions: The factors associated with symptom persistence, incomplete radiological resolution, and D[SUB]LCO[/SUB] <80% differed according to age, sex, comorbidities, and respiratory support. The burden of symptoms, reduced D[SUB]LCO[/SUB] , and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; RECOVID; SARS-CoV-2; SEPAR.
. 2023 Apr 10.
doi: 10.1111/joim.13642. Online ahead of print.
Residual pulmonary infiltrates, symptoms and diffusion impairment at one-year after severe COVID-19 infection have different associated factors
Rosario Menéndez[SUP] 1 2 3 4 [/SUP], Raúl Méndez[SUP] 1 2 3 4 [/SUP], Ana Latorre[SUP] 1 2 [/SUP], Paula González-Jiménez[SUP] 1 2 4 [/SUP], Germán Peces-Barba[SUP] 5 [/SUP], María Molina[SUP] 6 [/SUP], Pedro Pablo España[SUP] 7 [/SUP], Estela García[SUP] 8 [/SUP], Angélica Consuegra-Vanegas[SUP] 9 [/SUP], Ana Pando-Sandoval[SUP] 10 [/SUP], Carolina Panadero[SUP] 11 [/SUP], Juan Marco Figueira-Gonçalves[SUP] 12 [/SUP], David De la Rosa[SUP] 13 [/SUP], Oriol Sibila[SUP] 14 [/SUP], María Dolores Martínez-Pitarch[SUP] 15 [/SUP], Nuria Toledo[SUP] 16 [/SUP], Pilar Cejudo[SUP] 17 [/SUP], Wanda Almonte-Batista[SUP] 18 [/SUP], Abigail Macías-Paredes[SUP] 19 [/SUP], Diana Badenes[SUP] 20 [/SUP], Eli Nancy Pérez-Rodas[SUP] 21 [/SUP], Javier Lázaro[SUP] 22 [/SUP], Sarai Quirós[SUP] 23 [/SUP], Rosa Cordovilla[SUP] 24 [/SUP], Irene Cano-Pumarega[SUP] 3 25 [/SUP], Antoni Torres[SUP] 14 [/SUP]
Affiliations
- PMID: 37038609
- DOI: 10.1111/joim.13642
Abstract
Introduction: After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year follow-up. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (D[SUB]LCO[/SUB] ) at 1-year follow-up in patients from the Spanish Registry RECOVID.
Methods: RECOVID collected symptom and radiological and functional lung tests data on hospitalised patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits.
Results: Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae, and 31% had reduced D[SUB]LCO[/SUB] . Independently associated factors included female sex, asthma, and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO[SUB]2[/SUB] /FiO[SUB]2[/SUB] <450 or CURB65 ≥2. Reduced D[SUB]LCO[/SUB] was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO[SUB]2[/SUB] /FiO[SUB]2[/SUB] <450 and CURB-65 ≥2, and the requirement of respiratory support. At 12 months, a proportion of the asymptomatic patients showed reduced D[SUB]LCO[/SUB] (9.5%), radiological findings (25%), or both (11%).
Conclusions: The factors associated with symptom persistence, incomplete radiological resolution, and D[SUB]LCO[/SUB] <80% differed according to age, sex, comorbidities, and respiratory support. The burden of symptoms, reduced D[SUB]LCO[/SUB] , and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; RECOVID; SARS-CoV-2; SEPAR.