tetano
Editor, Senior Moderator
J Intern Med
. 2022 Aug 24.
doi: 10.1111/joim.13564. Online ahead of print.
Prevalence and 24-month recovery of olfactory dysfunction in COVID-19 patients: A multicenter prospective study
Jerome R Lechien[SUP] 1 2 3 4 [/SUP], Luigi A Vaira[SUP] 5 6 [/SUP], Sven Saussez[SUP] 2 4 [/SUP]
Affiliations
Abstract
Objective: To investigate prevalence and recovery of olfactory dysfunction (OD) in COVID-19 patients 24 months after the infection.
Methods: From March 22, 2020 to June 5, 2022, 251 COVID-19 patients were followed in three European medical centers. Olfactory function was assessed with subjective patient-reported outcome questionnaires and odor identification tests at baseline, 6-, 12-, 18- and 24-month post-infection. The predictive values of epidemiological and clinical data were investigated with multivariate analysis.
Results: One hundred and seventy-one patients completed the evaluations. The odor identification test revealed that 123 patients (50.8%) had OD at baseline. The prevalence of persistent psychophysical abnormalities at 6-, 12-, 18-, and 24-month post-COVID-19 was 24.2%, 17.9%, 5.8% and 2.9%, respectively (p = 0.001). Parosmia occurred in 40 patients (23.4%) and lasted 60±119 days. At 2 years, 51 patients (29.8%) self-reported that their olfaction was unnormalised. Older patients had better odor identification evaluations at baseline (p<0.001) but those with OD reported lower odor identification test scores at the end of the follow-up. Parosmia occurred more frequently in young patients. The olfactory training was significantly associated with higher values of Sniffin'Sticks tests at 18-month post-infection (r[SUB]s[/SUB] = 0.678; p<0.001).
Conclusion: Two years post-COVID-19, 29.8% of patients reported persistent OD, but only 2.9% had abnormal identification psychophysical evaluations. This article is protected by copyright. All rights reserved.
Keywords: Anosmia; COVID-19; Coronavirus; Hyposmia; Olfactory; Otolaryngology; Recovery; Rhinology; SARS-CoV-2; Serology; Smell.
. 2022 Aug 24.
doi: 10.1111/joim.13564. Online ahead of print.
Prevalence and 24-month recovery of olfactory dysfunction in COVID-19 patients: A multicenter prospective study
Jerome R Lechien[SUP] 1 2 3 4 [/SUP], Luigi A Vaira[SUP] 5 6 [/SUP], Sven Saussez[SUP] 2 4 [/SUP]
Affiliations
- PMID: 36000469
- DOI: 10.1111/joim.13564
Abstract
Objective: To investigate prevalence and recovery of olfactory dysfunction (OD) in COVID-19 patients 24 months after the infection.
Methods: From March 22, 2020 to June 5, 2022, 251 COVID-19 patients were followed in three European medical centers. Olfactory function was assessed with subjective patient-reported outcome questionnaires and odor identification tests at baseline, 6-, 12-, 18- and 24-month post-infection. The predictive values of epidemiological and clinical data were investigated with multivariate analysis.
Results: One hundred and seventy-one patients completed the evaluations. The odor identification test revealed that 123 patients (50.8%) had OD at baseline. The prevalence of persistent psychophysical abnormalities at 6-, 12-, 18-, and 24-month post-COVID-19 was 24.2%, 17.9%, 5.8% and 2.9%, respectively (p = 0.001). Parosmia occurred in 40 patients (23.4%) and lasted 60±119 days. At 2 years, 51 patients (29.8%) self-reported that their olfaction was unnormalised. Older patients had better odor identification evaluations at baseline (p<0.001) but those with OD reported lower odor identification test scores at the end of the follow-up. Parosmia occurred more frequently in young patients. The olfactory training was significantly associated with higher values of Sniffin'Sticks tests at 18-month post-infection (r[SUB]s[/SUB] = 0.678; p<0.001).
Conclusion: Two years post-COVID-19, 29.8% of patients reported persistent OD, but only 2.9% had abnormal identification psychophysical evaluations. This article is protected by copyright. All rights reserved.
Keywords: Anosmia; COVID-19; Coronavirus; Hyposmia; Olfactory; Otolaryngology; Recovery; Rhinology; SARS-CoV-2; Serology; Smell.