tetano
Editor, Senior Moderator
J Intern Med
. 2022 May 9.
doi: 10.1111/joim.13504. Online ahead of print.
Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adults
Laura C Myers[SUP] 1 [/SUP], Patricia Kipnis[SUP] 1 [/SUP], John Greene[SUP] 1 [/SUP], Brian Lawson[SUP] 1 [/SUP], Gabriel J Escobar[SUP] 1 [/SUP], Bruce H Fireman[SUP] 1 [/SUP], Nicola P Klein[SUP] 1 [/SUP], Vincent X Liu[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) breakthrough infections are common.
Objective: Evaluate in-hospital mortality of patients with COVID-19 by vaccination status using retrospective cohort study.
Methods: We generated propensity scores for receipt of full vaccination in adults requiring supplemental oxygen hospitalized at Kaiser Permanente Northern California (4/1/2021-11/30/2021) with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests. Optimal matching of fully vaccinated/unvaccinated patients was performed comparing in-hospital mortality.
Results: Of 7305 patients, 1463 (20.0%) were full, 138 (1.9%) were partial and 5704 (78.1%) were unvaccinated. Fully vaccinated were older than partial or unvaccinated (71.0, 63.0, 54.0 years, respectively, P < 0.001) with more comorbidities (Comorbidity Point Score 33.0, 22.0, 10.0, P < 0.001) and immunosuppressant (11.5%, 8.7%, 3.0%, P < 0.001) or chemotherapy exposure (2.8%, 0.7%, 0.4%, P < 0.001). Fewer fully vaccinated patients died compared to matched unvaccinated (9.0% vs 16.3%, P < 0.0001).
Conclusion: Fully vaccinated patients are less likely to die compared to matched unvaccinated patients. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; breakthrough infection; hospitalization; mortality; vaccination.
. 2022 May 9.
doi: 10.1111/joim.13504. Online ahead of print.
Adults hospitalized with breakthrough COVID-19 have lower mortality than matched unvaccinated adults
Laura C Myers[SUP] 1 [/SUP], Patricia Kipnis[SUP] 1 [/SUP], John Greene[SUP] 1 [/SUP], Brian Lawson[SUP] 1 [/SUP], Gabriel J Escobar[SUP] 1 [/SUP], Bruce H Fireman[SUP] 1 [/SUP], Nicola P Klein[SUP] 1 [/SUP], Vincent X Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 35531712
- DOI: 10.1111/joim.13504
Abstract
Background: Coronavirus disease 2019 (COVID-19) breakthrough infections are common.
Objective: Evaluate in-hospital mortality of patients with COVID-19 by vaccination status using retrospective cohort study.
Methods: We generated propensity scores for receipt of full vaccination in adults requiring supplemental oxygen hospitalized at Kaiser Permanente Northern California (4/1/2021-11/30/2021) with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests. Optimal matching of fully vaccinated/unvaccinated patients was performed comparing in-hospital mortality.
Results: Of 7305 patients, 1463 (20.0%) were full, 138 (1.9%) were partial and 5704 (78.1%) were unvaccinated. Fully vaccinated were older than partial or unvaccinated (71.0, 63.0, 54.0 years, respectively, P < 0.001) with more comorbidities (Comorbidity Point Score 33.0, 22.0, 10.0, P < 0.001) and immunosuppressant (11.5%, 8.7%, 3.0%, P < 0.001) or chemotherapy exposure (2.8%, 0.7%, 0.4%, P < 0.001). Fewer fully vaccinated patients died compared to matched unvaccinated (9.0% vs 16.3%, P < 0.0001).
Conclusion: Fully vaccinated patients are less likely to die compared to matched unvaccinated patients. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; breakthrough infection; hospitalization; mortality; vaccination.