tetano
Editor, Senior Moderator
J Intensive Care Med
. 2022 May 11;8850666221100411.
doi: 10.1177/08850666221100411. Online ahead of print.
Multi-inflammatory Index as a Novel Mortality Predictor in Critically Ill COVID-19 Patients
Hasan Tahsin Gozdas[SUP] 1 [/SUP], Seyit Ali Kayis[SUP] 2 [/SUP], Tugce Damarsoy[SUP] 1 [/SUP], Emine Ozsari[SUP] 3 [/SUP], Mustafa Turkoglu[SUP] 4 [/SUP], Isa Yildiz[SUP] 5 [/SUP], Abdullah Demirhan[SUP] 5 [/SUP]
Affiliations
Abstract
Aim: Systemic inflammation has a crucial role in the pathogenesis and mortality of Coronavirus disease 2019 (COVID-19). Multi-inflammatory index (MII) is a novel index related with systemic inflammation. In this study, we investigated the relationship between MII and in-hospital mortality in COVID-19 patients admitted to the intensive care unit (ICU).
Methods: We retrospectively analyzed the medical records of COVID-19 patients followed-up in the ICU of our institution between 01.04.2020 and 01.10.2021. Patients were classified into two groups according to mortality status as survivors and non-survivors. Various inflammatory parameters of the groups were compared and their efficacy in predicting mortality was investigated.
Results: Out of 348 study patients, 86 cases (24.7%) were in the survived group and 262 cases (75.3%) were in the dead group. The median age of the mortal group was significantly higher than that of the survived group (65.5 vs 76, P < .001). Multiple logistic regression analysis revealed that among all the included inflammatory parameters, MII showed the best efficacy for predicting mortality (OR: 0.999; 95% CI: 0.9991-0.9998; P = .003).
Conclusion: MII, a new combination of Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP), is a simple and practical biomarker that can help us in the prediction of mortality in COVID-19 patients followed-up in the ICU.
Keywords: coronavirus disease 2019; intensive care unit; mortality; multi-inflammatory index.
. 2022 May 11;8850666221100411.
doi: 10.1177/08850666221100411. Online ahead of print.
Multi-inflammatory Index as a Novel Mortality Predictor in Critically Ill COVID-19 Patients
Hasan Tahsin Gozdas[SUP] 1 [/SUP], Seyit Ali Kayis[SUP] 2 [/SUP], Tugce Damarsoy[SUP] 1 [/SUP], Emine Ozsari[SUP] 3 [/SUP], Mustafa Turkoglu[SUP] 4 [/SUP], Isa Yildiz[SUP] 5 [/SUP], Abdullah Demirhan[SUP] 5 [/SUP]
Affiliations
- PMID: 35538901
- DOI: 10.1177/08850666221100411
Abstract
Aim: Systemic inflammation has a crucial role in the pathogenesis and mortality of Coronavirus disease 2019 (COVID-19). Multi-inflammatory index (MII) is a novel index related with systemic inflammation. In this study, we investigated the relationship between MII and in-hospital mortality in COVID-19 patients admitted to the intensive care unit (ICU).
Methods: We retrospectively analyzed the medical records of COVID-19 patients followed-up in the ICU of our institution between 01.04.2020 and 01.10.2021. Patients were classified into two groups according to mortality status as survivors and non-survivors. Various inflammatory parameters of the groups were compared and their efficacy in predicting mortality was investigated.
Results: Out of 348 study patients, 86 cases (24.7%) were in the survived group and 262 cases (75.3%) were in the dead group. The median age of the mortal group was significantly higher than that of the survived group (65.5 vs 76, P < .001). Multiple logistic regression analysis revealed that among all the included inflammatory parameters, MII showed the best efficacy for predicting mortality (OR: 0.999; 95% CI: 0.9991-0.9998; P = .003).
Conclusion: MII, a new combination of Neutrophil to lymphocyte ratio (NLR) and C-reactive protein (CRP), is a simple and practical biomarker that can help us in the prediction of mortality in COVID-19 patients followed-up in the ICU.
Keywords: coronavirus disease 2019; intensive care unit; mortality; multi-inflammatory index.