tetano
Editor, Senior Moderator
J Int Med Res
. 2024 Mar;52(3):3000605241233450.
doi: 10.1177/03000605241233450. Onset of acute severe autoimmune hepatitis after severe acute respiratory syndrome coronavirus 2 infection: a case report
Yi-Jun Zhou[SUP] 1 [/SUP], Qiao-Fei Jin[SUP] 1 [/SUP], Chen Wang[SUP] 1 [/SUP], Xiao-Jing Zhang[SUP] 1 [/SUP], Hong Liu[SUP] 2 [/SUP], Jianfeng Bao[SUP] 1 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger autoimmune inflammation in the liver, leading to acute autoimmune hepatitis (AIH). We herein report a case involving a 39-year-old woman with a 23-day history of yellow skin and urine. Using the revised original scoring system of the International AIH Group, we definitively diagnosed the patient with acute severe AIH (AS-AIH). She began treatment with 80 mg/day intravenous methylprednisolone, which was gradually reduced and followed by eventual transition to oral methylprednisolone. The patient finally achieved a biochemical response after 30 days of therapy, and liver transplantation was avoided. Clinicians should be aware that the onset of AS-AIH after SARS-CoV-2 infection differs from the onset of conventional AIH with respect to its clinical and pathological features. Early diagnosis and timely glucocorticoid treatment are crucial in improving outcomes.
Keywords: Autoimmune hepatitis; SARS-CoV-2; acute; case report; glucocorticoid; liver transplantation.
. 2024 Mar;52(3):3000605241233450.
doi: 10.1177/03000605241233450. Onset of acute severe autoimmune hepatitis after severe acute respiratory syndrome coronavirus 2 infection: a case report
Yi-Jun Zhou[SUP] 1 [/SUP], Qiao-Fei Jin[SUP] 1 [/SUP], Chen Wang[SUP] 1 [/SUP], Xiao-Jing Zhang[SUP] 1 [/SUP], Hong Liu[SUP] 2 [/SUP], Jianfeng Bao[SUP] 1 [/SUP]
Affiliations
- PMID: 38502002
- PMCID: PMC10953009
- DOI: 10.1177/03000605241233450
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger autoimmune inflammation in the liver, leading to acute autoimmune hepatitis (AIH). We herein report a case involving a 39-year-old woman with a 23-day history of yellow skin and urine. Using the revised original scoring system of the International AIH Group, we definitively diagnosed the patient with acute severe AIH (AS-AIH). She began treatment with 80 mg/day intravenous methylprednisolone, which was gradually reduced and followed by eventual transition to oral methylprednisolone. The patient finally achieved a biochemical response after 30 days of therapy, and liver transplantation was avoided. Clinicians should be aware that the onset of AS-AIH after SARS-CoV-2 infection differs from the onset of conventional AIH with respect to its clinical and pathological features. Early diagnosis and timely glucocorticoid treatment are crucial in improving outcomes.
Keywords: Autoimmune hepatitis; SARS-CoV-2; acute; case report; glucocorticoid; liver transplantation.