tetano
Editor, Senior Moderator
J Inflamm Res
. 2023 Oct 31:16:4913-4924.
doi: 10.2147/JIR.S431212. eCollection 2023. CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
Yingli Liu[SUP] 1 [/SUP], Dan Si[SUP] 2 [/SUP], Pingping Bai[SUP] 3 [/SUP], Li Zhu[SUP] 4 [/SUP], Lili Zhang[SUP] 1 [/SUP], Qi Chen[SUP] 5 [/SUP], Yong Qi[SUP] 6 [/SUP]
Affiliations
Background: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients.
Methods: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein-protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples.
Results: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01).
Conclusion: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients.
Keywords: CXCL10; bioinformatics; coronavirus disease 2019; pulmonary embolism.
. 2023 Oct 31:16:4913-4924.
doi: 10.2147/JIR.S431212. eCollection 2023. CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients
Yingli Liu[SUP] 1 [/SUP], Dan Si[SUP] 2 [/SUP], Pingping Bai[SUP] 3 [/SUP], Li Zhu[SUP] 4 [/SUP], Lili Zhang[SUP] 1 [/SUP], Qi Chen[SUP] 5 [/SUP], Yong Qi[SUP] 6 [/SUP]
Affiliations
- PMID: 37927958
- PMCID: PMC10625331
- DOI: 10.2147/JIR.S431212
Background: Although the potential of coronavirus disease 2019 (COVID-19) patients to develop pulmonary embolism (PE) is widely recognized, the underlying mechanism has not been completely elucidated. This study aimed to identify genes common to COVID-19 and PE to reveal the underlying pathogenesis of susceptibility to PE in COVID-19 patients.
Methods: COVID-19 genes were obtained from the GEO database and the OMIM, CTD, GeneCards, and DisGeNET databases; PE genes were obtained from the OMIM, CTD, GeneCards, and DisGeNET databases. We overlapped the genes of COVID-19 and PE to obtain common genes for additional analysis, including functional enrichment, protein-protein interaction, and immune infiltration analysis. Hub genes were identified using cytoHubba, a plugin of Cytoscape, and validated using the independent datasets GSE167000 and GSE13535. The genes validated by the above datasets were further validated in clinical samples.
Results: We obtained 36 genes shared by PE and COVID-19. Functional enrichment and immune infiltration analyses revealed the involvement of cytokines and immune activation. Five genes (CCL2, CXCL10, ALB, EGF, and MKI67) were identified as hub genes common to COVID-19 and PE. CXCL10 was validated in both independent datasets (GSE167000 and GSE13535). Serum levels of CXCL10 in the COVID-19 group and the COVID-19 combined with PE group were significantly higher than those in the healthy control group (P<0.001). In addition, there were significant differences between the COVID-19 group and the COVID-19 combined with PE group (P<0.01).
Conclusion: Our study reveals common genes shared by PE and COVID-19 and identifies CXCL10 as a possible cause of susceptibility to PE in COVID-19 patients.
Keywords: CXCL10; bioinformatics; coronavirus disease 2019; pulmonary embolism.