tetano
Editor, Senior Moderator
J Infect
. 2024 Sep 26:106292.
doi: 10.1016/j.jinf.2024.106292. Online ahead of print. Severity of Respiratory Syncytial Virus compared with SARS-CoV-2 and Influenza among hospitalised adults ≥65 years
Lorena Vega-Piris[SUP] 1 [/SUP], Silvia Galindo Carretero[SUP] 2 [/SUP], José Luis Mayordomo[SUP] 3 [/SUP], Mercedes Belén Rumayor Zarzuelo[SUP] 4 [/SUP], Virginia Álvarez Río[SUP] 5 [/SUP], Virtudes Gallardo García[SUP] 6 [/SUP], Miriam García Vázquez[SUP] 7 [/SUP], María Del Carmen García Rodríguez[SUP] 8 [/SUP], Luca Basile[SUP] 9 [/SUP], Nieves López González-Coviella[SUP] 10 [/SUP], Maria Isabel Barranco Boada[SUP] 11 [/SUP], Olaia Pérez-Martínez[SUP] 12 [/SUP], Ana Lameiras Azevedo[SUP] 13 [/SUP], Carmen Quiñones Rubio[SUP] 14 [/SUP], Jaume Giménez Duran[SUP] 15 [/SUP], Ana Fernández Ibáñez[SUP] 16 [/SUP], María Victoria García Rivera[SUP] 17 [/SUP], Violeta Ramos Marín[SUP] 18 [/SUP], Daniel Castrillejo[SUP] 19 [/SUP], Luis Javier Viloria Raymundo[SUP] 20 [/SUP], Amparo Larrauri[SUP] 21 [/SUP], Susana Monge[SUP] 22 [/SUP]; SARI Sentinel Surveillance Group
Affiliations
Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19.
Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2.
Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR=0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81(0.67-0.98)], ICU admission [vs. influenza: 0.93(0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64(0.32-1.28); vs. SARS-CoV-2: 0.56(0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.
Keywords: ICU admission; SARS-CoV2; influenza; mortality; pneumonia; severe acute respiratory infection; syncytial respiratory virus; vaccination.
. 2024 Sep 26:106292.
doi: 10.1016/j.jinf.2024.106292. Online ahead of print. Severity of Respiratory Syncytial Virus compared with SARS-CoV-2 and Influenza among hospitalised adults ≥65 years
Lorena Vega-Piris[SUP] 1 [/SUP], Silvia Galindo Carretero[SUP] 2 [/SUP], José Luis Mayordomo[SUP] 3 [/SUP], Mercedes Belén Rumayor Zarzuelo[SUP] 4 [/SUP], Virginia Álvarez Río[SUP] 5 [/SUP], Virtudes Gallardo García[SUP] 6 [/SUP], Miriam García Vázquez[SUP] 7 [/SUP], María Del Carmen García Rodríguez[SUP] 8 [/SUP], Luca Basile[SUP] 9 [/SUP], Nieves López González-Coviella[SUP] 10 [/SUP], Maria Isabel Barranco Boada[SUP] 11 [/SUP], Olaia Pérez-Martínez[SUP] 12 [/SUP], Ana Lameiras Azevedo[SUP] 13 [/SUP], Carmen Quiñones Rubio[SUP] 14 [/SUP], Jaume Giménez Duran[SUP] 15 [/SUP], Ana Fernández Ibáñez[SUP] 16 [/SUP], María Victoria García Rivera[SUP] 17 [/SUP], Violeta Ramos Marín[SUP] 18 [/SUP], Daniel Castrillejo[SUP] 19 [/SUP], Luis Javier Viloria Raymundo[SUP] 20 [/SUP], Amparo Larrauri[SUP] 21 [/SUP], Susana Monge[SUP] 22 [/SUP]; SARI Sentinel Surveillance Group
Affiliations
- PMID: 39341402
- DOI: 10.1016/j.jinf.2024.106292
Introduction: Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19.
Methods: We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2.
Results: Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR=0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81(0.67-0.98)], ICU admission [vs. influenza: 0.93(0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64(0.32-1.28); vs. SARS-CoV-2: 0.56(0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.
Keywords: ICU admission; SARS-CoV2; influenza; mortality; pneumonia; severe acute respiratory infection; syncytial respiratory virus; vaccination.