tetano
Editor, Senior Moderator
J Infect Public Health
. 2021 Apr 23;14(7):863-875.
doi: 10.1016/j.jiph.2021.04.005. Online ahead of print.
SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies-a narrative review
Rakesh Kumar[SUP] 1 [/SUP], Cut Meurah Yeni[SUP] 2 [/SUP], Niken Asri Utami[SUP] 3 [/SUP], Rupali Masand[SUP] 4 [/SUP], Rajesh Kumar Asrani[SUP] 5 [/SUP], Shailesh Kumar Patel[SUP] 6 [/SUP], Akshay Kumar[SUP] 7 [/SUP], Mohd Iqbal Yatoo[SUP] 8 [/SUP], Ruchi Tiwari[SUP] 9 [/SUP], Senthilkumar Natesan[SUP] 10 [/SUP], Kranti Suresh Vora[SUP] 11 [/SUP], Firzan Nainu[SUP] 12 [/SUP], Muhammad Bilal[SUP] 13 [/SUP], Manish Dhawan[SUP] 14 [/SUP], Talha Bin Emran[SUP] 15 [/SUP], Tauseef Ahmad[SUP] 16 [/SUP], Harapan Harapan[SUP] 17 [/SUP], Kuldeep Dhama[SUP] 18 [/SUP]
Affiliations
Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health problem. The SARS-CoV-2 triggers hyper-activation of inflammatory and immune responses resulting in cytokine storm and increased inflammatory responses on several organs like lungs, kidneys, intestine, and placenta. Although SARS-CoV-2 affects individuals of all age groups and physiological statuses, immune-compromised individuals such as pregnant women are considered as a highly vulnerable group. This review aims to raise the concerns of high risk of infection, morbidity and mortality of COVID-19 in pregnant women and provides critical reviews of pathophysiology and pathobiology of how SARS-CoV-2 infection potentially increases the severity and fatality during pregnancy. This article also provides a discussion of current evidence on vertical transmission of SARS-CoV-2 during pregnancy and breastfeeding. Lastly, guidelines on management, treatment, preventive, and mitigation strategies of SARS-CoV-2 infection during pregnancy and pregnancy-related conditions such as delivery and breastfeeding are discussed.
Keywords: COVID-19; Pregnant women; Prevention; SARS-CoV-2; Vertical transmission.
. 2021 Apr 23;14(7):863-875.
doi: 10.1016/j.jiph.2021.04.005. Online ahead of print.
SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies-a narrative review
Rakesh Kumar[SUP] 1 [/SUP], Cut Meurah Yeni[SUP] 2 [/SUP], Niken Asri Utami[SUP] 3 [/SUP], Rupali Masand[SUP] 4 [/SUP], Rajesh Kumar Asrani[SUP] 5 [/SUP], Shailesh Kumar Patel[SUP] 6 [/SUP], Akshay Kumar[SUP] 7 [/SUP], Mohd Iqbal Yatoo[SUP] 8 [/SUP], Ruchi Tiwari[SUP] 9 [/SUP], Senthilkumar Natesan[SUP] 10 [/SUP], Kranti Suresh Vora[SUP] 11 [/SUP], Firzan Nainu[SUP] 12 [/SUP], Muhammad Bilal[SUP] 13 [/SUP], Manish Dhawan[SUP] 14 [/SUP], Talha Bin Emran[SUP] 15 [/SUP], Tauseef Ahmad[SUP] 16 [/SUP], Harapan Harapan[SUP] 17 [/SUP], Kuldeep Dhama[SUP] 18 [/SUP]
Affiliations
- PMID: 34118736
- DOI: 10.1016/j.jiph.2021.04.005
Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health problem. The SARS-CoV-2 triggers hyper-activation of inflammatory and immune responses resulting in cytokine storm and increased inflammatory responses on several organs like lungs, kidneys, intestine, and placenta. Although SARS-CoV-2 affects individuals of all age groups and physiological statuses, immune-compromised individuals such as pregnant women are considered as a highly vulnerable group. This review aims to raise the concerns of high risk of infection, morbidity and mortality of COVID-19 in pregnant women and provides critical reviews of pathophysiology and pathobiology of how SARS-CoV-2 infection potentially increases the severity and fatality during pregnancy. This article also provides a discussion of current evidence on vertical transmission of SARS-CoV-2 during pregnancy and breastfeeding. Lastly, guidelines on management, treatment, preventive, and mitigation strategies of SARS-CoV-2 infection during pregnancy and pregnancy-related conditions such as delivery and breastfeeding are discussed.
Keywords: COVID-19; Pregnant women; Prevention; SARS-CoV-2; Vertical transmission.