tetano
Editor, Senior Moderator
J Infect Public Health
. 2024 Oct 28;17(12):102570.
doi: 10.1016/j.jiph.2024.102570. Online ahead of print. Risk of admission requirement among children with respiratory infection in the post-COVID-19 pandemic era
Takahiro Mori[SUP] 1 [/SUP], Taito Kitano[SUP] 2 [/SUP], Daisuke Kitagawa[SUP] 3 [/SUP], Masayuki Murata[SUP] 1 [/SUP], Mai Onishi[SUP] 1 [/SUP], Soshi Hachisuka[SUP] 1 [/SUP], Tenshin Okubo[SUP] 1 [/SUP], Naohiro Yamamoto[SUP] 1 [/SUP], Hiroki Nishikawa[SUP] 1 [/SUP], Masayuki Onaka[SUP] 1 [/SUP], Rika Suzuki[SUP] 1 [/SUP], Madoka Sekine[SUP] 3 [/SUP], Soma Suzuki[SUP] 3 [/SUP], Fumihiko Nakamura[SUP] 3 [/SUP], Sayaka Yoshida[SUP] 1 [/SUP]
Affiliations
Background: To evaluate the effect of the type and codetection of respiratory viruses on admission requirements among children with respiratory infections in the post-COVID-19 pandemic era.
Methods: In this retrospective study, we analyzed patients with acute respiratory symptoms using FilmArray® Respiratory Panel between December 2020 and March 2024. The viruses were classified into eight groups: adenovirus, seasonal coronavirus, human metapneumovirus, human rhinovirus/enterovirus, influenza virus, parainfluenza virus, respiratory syncytial virus, and severe acute respiratory virus coronavirus-2. The impact of the detected viral groups and viral codetection on hospitalization rates were examined using multivariable regression analysis in three pediatric age groups (<2 years, 2-4 years, and 5-17 years).
Results: A total of 4684 tests were performed, of which 3555 (75.9 %) tested positive for at least one respiratory virus and negative for atypical bacteria. Of these, 946 (26.6 %) were hospitalized. Multivariable regression analyses showed that respiratory syncytial virus (RSV) infection was associated with hospitalization requirement among young children (adjusted odds ratios (aOR) 2.46 [1.65-3.67], p < 0.001 in < 2 years, and 1.34 [1.02-2.30], p = 0.042 in 2-4 years). Influenza (aOR 0.23 [0.07-0.83], p = 0.025) and SARS-CoV-2 (aOR 0.39 [0.22-0.69], p = 0.001) were negatively correlated with hospitalization among children younger than 2 years. Viral codetection was not significantly associated with hospitalization in any pediatric age group.
Conclusion: RSV infection was associated with a higher risk of hospitalization in children younger than 5 years than other respiratory viruses. These results highlight the importance of preventive measures against RSV infections, including maternal vaccination and childhood immunization.
Keywords: Children; Influenza; Respiratory syncytial virus; Respiratory tract infections; SARS-CoV-2.
. 2024 Oct 28;17(12):102570.
doi: 10.1016/j.jiph.2024.102570. Online ahead of print. Risk of admission requirement among children with respiratory infection in the post-COVID-19 pandemic era
Takahiro Mori[SUP] 1 [/SUP], Taito Kitano[SUP] 2 [/SUP], Daisuke Kitagawa[SUP] 3 [/SUP], Masayuki Murata[SUP] 1 [/SUP], Mai Onishi[SUP] 1 [/SUP], Soshi Hachisuka[SUP] 1 [/SUP], Tenshin Okubo[SUP] 1 [/SUP], Naohiro Yamamoto[SUP] 1 [/SUP], Hiroki Nishikawa[SUP] 1 [/SUP], Masayuki Onaka[SUP] 1 [/SUP], Rika Suzuki[SUP] 1 [/SUP], Madoka Sekine[SUP] 3 [/SUP], Soma Suzuki[SUP] 3 [/SUP], Fumihiko Nakamura[SUP] 3 [/SUP], Sayaka Yoshida[SUP] 1 [/SUP]
Affiliations
- PMID: 39481292
- DOI: 10.1016/j.jiph.2024.102570
Background: To evaluate the effect of the type and codetection of respiratory viruses on admission requirements among children with respiratory infections in the post-COVID-19 pandemic era.
Methods: In this retrospective study, we analyzed patients with acute respiratory symptoms using FilmArray® Respiratory Panel between December 2020 and March 2024. The viruses were classified into eight groups: adenovirus, seasonal coronavirus, human metapneumovirus, human rhinovirus/enterovirus, influenza virus, parainfluenza virus, respiratory syncytial virus, and severe acute respiratory virus coronavirus-2. The impact of the detected viral groups and viral codetection on hospitalization rates were examined using multivariable regression analysis in three pediatric age groups (<2 years, 2-4 years, and 5-17 years).
Results: A total of 4684 tests were performed, of which 3555 (75.9 %) tested positive for at least one respiratory virus and negative for atypical bacteria. Of these, 946 (26.6 %) were hospitalized. Multivariable regression analyses showed that respiratory syncytial virus (RSV) infection was associated with hospitalization requirement among young children (adjusted odds ratios (aOR) 2.46 [1.65-3.67], p < 0.001 in < 2 years, and 1.34 [1.02-2.30], p = 0.042 in 2-4 years). Influenza (aOR 0.23 [0.07-0.83], p = 0.025) and SARS-CoV-2 (aOR 0.39 [0.22-0.69], p = 0.001) were negatively correlated with hospitalization among children younger than 2 years. Viral codetection was not significantly associated with hospitalization in any pediatric age group.
Conclusion: RSV infection was associated with a higher risk of hospitalization in children younger than 5 years than other respiratory viruses. These results highlight the importance of preventive measures against RSV infections, including maternal vaccination and childhood immunization.
Keywords: Children; Influenza; Respiratory syncytial virus; Respiratory tract infections; SARS-CoV-2.