tetano
Editor, Senior Moderator
J Infect Public Health
. 2022 Dec 12;16(1):136-142.
doi: 10.1016/j.jiph.2022.12.009. Online ahead of print.
Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study
Antonio Russo[SUP] 1 [/SUP], Mariantonietta Pisaturo[SUP] 1 [/SUP], Ilaria De Luca[SUP] 1 [/SUP], Ferdinando Schettino[SUP] 2 [/SUP], Paolo Maggi[SUP] 3 [/SUP], Fabio Giuliano Numis[SUP] 4 [/SUP], Ivan Gentile[SUP] 5 [/SUP], Vincenzo Sangiovanni[SUP] 6 [/SUP], Anna Maria Rossomando[SUP] 7 [/SUP], Valeria Gentile[SUP] 8 [/SUP], Giosuele Calabria[SUP] 9 [/SUP], Caroliona Rescigno[SUP] 10 [/SUP], Angelo Salomone Megna[SUP] 11 [/SUP], Alfonso Masullo[SUP] 12 [/SUP], Elio Manzillo[SUP] 13 [/SUP], Grazia Russo[SUP] 14 [/SUP], Roberto Parrella[SUP] 15 [/SUP], Giuseppina Dell'Aquila[SUP] 16 [/SUP], Michele Gambardella[SUP] 17 [/SUP], Antonio Ponticiello[SUP] 18 [/SUP], Alfonso Reginelli[SUP] 2 [/SUP], Nicola Coppola[SUP] 19 [/SUP]; CoviCam group
Affiliations
Abstract
Introduction: Since the beginning of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic an important tool for patients with Coronavirus Disease 2019 (COVID-19) has been the computed tomography (CT) scan, but not always available in some settings The aim was to find a cut-off that can predict worsening in patients with COVID-19 assessed with a computed tomography (CT) scan and to find laboratory, clinical or demographic parameters that may correlate with a higher CT score.
Methods: We performed a multi-center, observational, retrospective study involving seventeen COVID-19 Units in southern Italy, including all 321 adult patients hospitalized with a diagnosis of COVID-19 who underwent at admission a CT evaluated using Pan score.
Results: Considering the clinical outcome and Pan score, the best cut-off point to discriminate a severe outcome was 12.5. High lactate dehydrogenase (LDH) serum value and low PaO2/FiO2 ratio (P/F) resulted independently associated with a high CT score. The Area Under Curve (AUC) analysis showed that the best cut-off point for LDH was 367.5 U/L and for P/F 164.5. Moreover, the patients with LDH> 367.5 U/L and P/F < 164.5 showed more frequently a severe CT score than those with LDH< 367.5 U/L and P/F> 164.5, 83.4%, vs 20%, respectively.
Conclusions: A direct correlation was observed between CT score value and outcome of COVID-19, such as CT score and high LDH levels and low P/F ratio at admission. Clinical or laboratory tools that predict the outcome at admission to hospital are useful to avoiding the overload of hospital facilities.
Keywords: COVID-19; CT score; Pan score; SARS-CoV-2 infection; Severity of disease.
. 2022 Dec 12;16(1):136-142.
doi: 10.1016/j.jiph.2022.12.009. Online ahead of print.
Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study
Antonio Russo[SUP] 1 [/SUP], Mariantonietta Pisaturo[SUP] 1 [/SUP], Ilaria De Luca[SUP] 1 [/SUP], Ferdinando Schettino[SUP] 2 [/SUP], Paolo Maggi[SUP] 3 [/SUP], Fabio Giuliano Numis[SUP] 4 [/SUP], Ivan Gentile[SUP] 5 [/SUP], Vincenzo Sangiovanni[SUP] 6 [/SUP], Anna Maria Rossomando[SUP] 7 [/SUP], Valeria Gentile[SUP] 8 [/SUP], Giosuele Calabria[SUP] 9 [/SUP], Caroliona Rescigno[SUP] 10 [/SUP], Angelo Salomone Megna[SUP] 11 [/SUP], Alfonso Masullo[SUP] 12 [/SUP], Elio Manzillo[SUP] 13 [/SUP], Grazia Russo[SUP] 14 [/SUP], Roberto Parrella[SUP] 15 [/SUP], Giuseppina Dell'Aquila[SUP] 16 [/SUP], Michele Gambardella[SUP] 17 [/SUP], Antonio Ponticiello[SUP] 18 [/SUP], Alfonso Reginelli[SUP] 2 [/SUP], Nicola Coppola[SUP] 19 [/SUP]; CoviCam group
Affiliations
- PMID: 36521329
- DOI: 10.1016/j.jiph.2022.12.009
Abstract
Introduction: Since the beginning of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic an important tool for patients with Coronavirus Disease 2019 (COVID-19) has been the computed tomography (CT) scan, but not always available in some settings The aim was to find a cut-off that can predict worsening in patients with COVID-19 assessed with a computed tomography (CT) scan and to find laboratory, clinical or demographic parameters that may correlate with a higher CT score.
Methods: We performed a multi-center, observational, retrospective study involving seventeen COVID-19 Units in southern Italy, including all 321 adult patients hospitalized with a diagnosis of COVID-19 who underwent at admission a CT evaluated using Pan score.
Results: Considering the clinical outcome and Pan score, the best cut-off point to discriminate a severe outcome was 12.5. High lactate dehydrogenase (LDH) serum value and low PaO2/FiO2 ratio (P/F) resulted independently associated with a high CT score. The Area Under Curve (AUC) analysis showed that the best cut-off point for LDH was 367.5 U/L and for P/F 164.5. Moreover, the patients with LDH> 367.5 U/L and P/F < 164.5 showed more frequently a severe CT score than those with LDH< 367.5 U/L and P/F> 164.5, 83.4%, vs 20%, respectively.
Conclusions: A direct correlation was observed between CT score value and outcome of COVID-19, such as CT score and high LDH levels and low P/F ratio at admission. Clinical or laboratory tools that predict the outcome at admission to hospital are useful to avoiding the overload of hospital facilities.
Keywords: COVID-19; CT score; Pan score; SARS-CoV-2 infection; Severity of disease.