tetano
Editor, Senior Moderator
J Infect Public Health
. 2022 Oct 13;15(11):1212-1224.
doi: 10.1016/j.jiph.2022.10.006. Online ahead of print.
A systematic review of current status and challenges of vaccinating children against SARS-CoV-2
Mengxin Zhang[SUP] 1 [/SUP], Pin Zhang[SUP] 1 [/SUP], Ying Liang[SUP] 1 [/SUP], Bang Du[SUP] 1 [/SUP], Lifeng Li[SUP] 1 [/SUP], Zhidan Yu[SUP] 1 [/SUP], Huanmin Wang[SUP] 1 [/SUP], Qionglin Wang[SUP] 2 [/SUP], Xianwei Zhang[SUP] 3 [/SUP], Wancun Zhang[SUP] 4 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has inflicted immense damage to countries, economies and societies worldwide. Authorized COVID-19 vaccines based on different platforms have been widely inoculated in adults, showing up to 100% immunogenicity with significant efficacy in preventing SARS-CoV-2 infections and the occurrence of severe COVID-19. It has also greatly slowed the evolution of SARS-CoV-2 variants, as shown in clinical trials and real-world evidence. However, the total dosage of COVID-19 vaccines for children is much smaller than that for adults due to limitations from parental concern of vaccine safety, presenting a potential obstacle in ending the COVID-19 pandemic. SARS-CoV-2 not only increases the risk of severe multisystem inflammatory syndrome (MIS-C) in children, but also negatively affects children's psychology and academics, indirectly hindering the maintenance and progress of normal social order. Therefore, this article examines the clinical manifestations of children infected with SARS-CoV-2, the status of vaccination against COVID-19 in children, vaccination-related adverse events, and the unique immune mechanisms of children. In particular, the necessity and challenges of vaccinating children against SARS-CoV-2 were highlighted from the perspectives of society and family. In summary, parental hesitancy is unnecessary as adverse events after COVID-19 vaccination have been proven to be infrequent, comprise of mild symptoms, and have a good prognosis.
Keywords: Adverse event; COVID-19; Children; MIS-C; Omicron; SARS-CoV-2; Vaccine.
. 2022 Oct 13;15(11):1212-1224.
doi: 10.1016/j.jiph.2022.10.006. Online ahead of print.
A systematic review of current status and challenges of vaccinating children against SARS-CoV-2
Mengxin Zhang[SUP] 1 [/SUP], Pin Zhang[SUP] 1 [/SUP], Ying Liang[SUP] 1 [/SUP], Bang Du[SUP] 1 [/SUP], Lifeng Li[SUP] 1 [/SUP], Zhidan Yu[SUP] 1 [/SUP], Huanmin Wang[SUP] 1 [/SUP], Qionglin Wang[SUP] 2 [/SUP], Xianwei Zhang[SUP] 3 [/SUP], Wancun Zhang[SUP] 4 [/SUP]
Affiliations
- PMID: 36257126
- DOI: 10.1016/j.jiph.2022.10.006
Abstract
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has inflicted immense damage to countries, economies and societies worldwide. Authorized COVID-19 vaccines based on different platforms have been widely inoculated in adults, showing up to 100% immunogenicity with significant efficacy in preventing SARS-CoV-2 infections and the occurrence of severe COVID-19. It has also greatly slowed the evolution of SARS-CoV-2 variants, as shown in clinical trials and real-world evidence. However, the total dosage of COVID-19 vaccines for children is much smaller than that for adults due to limitations from parental concern of vaccine safety, presenting a potential obstacle in ending the COVID-19 pandemic. SARS-CoV-2 not only increases the risk of severe multisystem inflammatory syndrome (MIS-C) in children, but also negatively affects children's psychology and academics, indirectly hindering the maintenance and progress of normal social order. Therefore, this article examines the clinical manifestations of children infected with SARS-CoV-2, the status of vaccination against COVID-19 in children, vaccination-related adverse events, and the unique immune mechanisms of children. In particular, the necessity and challenges of vaccinating children against SARS-CoV-2 were highlighted from the perspectives of society and family. In summary, parental hesitancy is unnecessary as adverse events after COVID-19 vaccination have been proven to be infrequent, comprise of mild symptoms, and have a good prognosis.
Keywords: Adverse event; COVID-19; Children; MIS-C; Omicron; SARS-CoV-2; Vaccine.