tetano
Editor, Senior Moderator
J Infect
. 2023 Jan 13;S0163-4453(23)00003-8.
doi: 10.1016/j.jinf.2023.01.004. Online ahead of print.
Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,064 patients hospitalised during the 2016-17 and 2017-18 influenza seasons
Mark Reacher[SUP] 1 [/SUP], Ben Warne[SUP] 2 [/SUP], Neville Q Verlander[SUP] 3 [/SUP], Ashley Popay[SUP] 4 [/SUP], Lucy Reeve[SUP] 5 [/SUP], Nicholas K Jones[SUP] 6 [/SUP], Kyriaki Ranellou[SUP] 7 [/SUP], Nyaradzai Sithole[SUP] 8 [/SUP], Rory Carpenter[SUP] 9 [/SUP], Angharad Everden[SUP] 10 [/SUP], Elizabeth Jarman[SUP] 11 [/SUP], Ali Khalid[SUP] 12 [/SUP], Kyle Lam[SUP] 13 [/SUP], Chloe Myers[SUP] 14 [/SUP], Shuhui Ren[SUP] 15 [/SUP], Kathryn J Rolfe[SUP] 16 [/SUP], Tommy Sutton[SUP] 17 [/SUP], Silvana Christou[SUP] 18 [/SUP], Callum Wright[SUP] 19 [/SUP], Saher Choudhry[SUP] 20 [/SUP], Maria Zambon[SUP] 21 [/SUP], Clare Sander[SUP] 22 [/SUP], Hongyi Zhang[SUP] 23 [/SUP], Hamid Jalal[SUP] 24 [/SUP]
Affiliations
Abstract
Standard course oseltamivir 75mg two times daily for five days was associated with an 82% reduction of odds of in-patient death (OR 0.18 (0.07,0.51)) compared to no oseltamivir treatment (OR 1.0 Reference) in a final multivariable logistic regression model of a retrospective cohort of PCR confirmed influenza B and influenza A (H3N2) infected patients admitted to a large UK teaching hospital in influenza seasons 2016-17 and 2017-18. No difference of protective odds for standard course oseltamivir was observed between influenza B and influenza A (H3N2) nor between influenza seasons. These observations strongly support clinical guidelines for molecular testing for respiratory viruses on admission to hospital and prompt treatment of confirmed seasonal influenza B and A with oseltamivir 75mg twice daily for five days.
Keywords: Historic Cohort study; PCR; influenza A (H3N2) in-patient mortality; influenza B; logistic regression; multiplex PCR; multivariable logistic regression.
. 2023 Jan 13;S0163-4453(23)00003-8.
doi: 10.1016/j.jinf.2023.01.004. Online ahead of print.
Oseltamivir is protective for in-patient mortality in PCR confirmed influenza B and influenza A(H3N2) infections in an historic cohort of 1,064 patients hospitalised during the 2016-17 and 2017-18 influenza seasons
Mark Reacher[SUP] 1 [/SUP], Ben Warne[SUP] 2 [/SUP], Neville Q Verlander[SUP] 3 [/SUP], Ashley Popay[SUP] 4 [/SUP], Lucy Reeve[SUP] 5 [/SUP], Nicholas K Jones[SUP] 6 [/SUP], Kyriaki Ranellou[SUP] 7 [/SUP], Nyaradzai Sithole[SUP] 8 [/SUP], Rory Carpenter[SUP] 9 [/SUP], Angharad Everden[SUP] 10 [/SUP], Elizabeth Jarman[SUP] 11 [/SUP], Ali Khalid[SUP] 12 [/SUP], Kyle Lam[SUP] 13 [/SUP], Chloe Myers[SUP] 14 [/SUP], Shuhui Ren[SUP] 15 [/SUP], Kathryn J Rolfe[SUP] 16 [/SUP], Tommy Sutton[SUP] 17 [/SUP], Silvana Christou[SUP] 18 [/SUP], Callum Wright[SUP] 19 [/SUP], Saher Choudhry[SUP] 20 [/SUP], Maria Zambon[SUP] 21 [/SUP], Clare Sander[SUP] 22 [/SUP], Hongyi Zhang[SUP] 23 [/SUP], Hamid Jalal[SUP] 24 [/SUP]
Affiliations
- PMID: 36646142
- DOI: 10.1016/j.jinf.2023.01.004
Abstract
Standard course oseltamivir 75mg two times daily for five days was associated with an 82% reduction of odds of in-patient death (OR 0.18 (0.07,0.51)) compared to no oseltamivir treatment (OR 1.0 Reference) in a final multivariable logistic regression model of a retrospective cohort of PCR confirmed influenza B and influenza A (H3N2) infected patients admitted to a large UK teaching hospital in influenza seasons 2016-17 and 2017-18. No difference of protective odds for standard course oseltamivir was observed between influenza B and influenza A (H3N2) nor between influenza seasons. These observations strongly support clinical guidelines for molecular testing for respiratory viruses on admission to hospital and prompt treatment of confirmed seasonal influenza B and A with oseltamivir 75mg twice daily for five days.
Keywords: Historic Cohort study; PCR; influenza A (H3N2) in-patient mortality; influenza B; logistic regression; multiplex PCR; multivariable logistic regression.