Giuseppe
Emeritus
Infection Of Immunocompromised Human By Avian H9n2 Influenza A Virus (J Infect., abstract, edited)
[Source: ScienceDirect, full text: <cite cite="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WJT-528907Y-1&_user=10&_coverDate=02%2F26%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a272db8effb0d6e709c6fbb5e3c50d91&searchtype=a">ScienceDirect - Journal of Infection : Infection Of Immunocompromised Human By Avian H9n2 Influenza A Virus</cite>. Abstract, edited.]
doi:10.1016/j.jinf.2011.02.007
Copyright ? 2011 Published by Elsevier Ltd.
Infection Of Immunocompromised Human By Avian H9n2 Influenza A Virus
Vincent C.C. Cheng 1, Jasper F.W. Chan 1, X. Wen 1, 2, W.L. Wu 1, 2, T.L. Que 4, H. Chen 1, 2, 3, K.H. Chan 1 and K.Y. Yuen 1, 2, 3
(1) State Key Laboratory for Emerging Infectious Diseases
(2) Department of Microbiology
(3) Research Center of Infection and Immunology The University of Hong Kong
(4) Department of Pathology Tuen Mun Hospital, Hong Kong Special Administrative Region, China
Received 1 June 2010; accepted 19 February 2011. Available online 26 February 2011.
Abstract
Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two immunocompromised patients cases of human infection by the virus in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft versus host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.
Keywords: Avian Influenza A H9N2; Bone marrow transplantation; Immunocompromised host
Correspondence to: K.Y. Yuen Carol Yu's Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China. Tel: +852-22553206, +852-28724555.
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doi:10.1016/j.jinf.2011.02.007
Copyright ? 2011 Published by Elsevier Ltd.
Infection Of Immunocompromised Human By Avian H9n2 Influenza A Virus
Vincent C.C. Cheng 1, Jasper F.W. Chan 1, X. Wen 1, 2, W.L. Wu 1, 2, T.L. Que 4, H. Chen 1, 2, 3, K.H. Chan 1 and K.Y. Yuen 1, 2, 3
(1) State Key Laboratory for Emerging Infectious Diseases
(2) Department of Microbiology
(3) Research Center of Infection and Immunology The University of Hong Kong
(4) Department of Pathology Tuen Mun Hospital, Hong Kong Special Administrative Region, China
Received 1 June 2010; accepted 19 February 2011. Available online 26 February 2011.
Abstract
Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two immunocompromised patients cases of human infection by the virus in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft versus host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.
Keywords: Avian Influenza A H9N2; Bone marrow transplantation; Immunocompromised host
Correspondence to: K.Y. Yuen Carol Yu's Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China. Tel: +852-22553206, +852-28724555.
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