tetano
Editor, Senior Moderator
J Infect Dis
. 2021 Dec 24;jiab624.
doi: 10.1093/infdis/jiab624. Online ahead of print.
Vaccine Effectiveness against Influenza Hospitalization and Emergency Department Visits in Two A(H3N2) Dominant Influenza Seasons among Children <18 Years Old, New Vaccine Surveillance Network 2016-17 and 2017-18
Sara S Kim[SUP] 1 [/SUP], Eric A Naioti[SUP] 1 2 [/SUP], Natasha B Halasa[SUP] 3 [/SUP], Laura S Stewart[SUP] 3 [/SUP], John V Williams[SUP] 4 [/SUP], Marian G Michaels[SUP] 4 [/SUP], Rangaraj Selvarangan[SUP] 5 6 [/SUP], Christopher J Harrison[SUP] 5 [/SUP], Mary A Staat[SUP] 7 [/SUP], Elizabeth P Schlaudecker[SUP] 7 [/SUP], Geoffrey A Weinberg[SUP] 8 [/SUP], Peter G Szilagyi[SUP] 8 9 [/SUP], Julie A Boom[SUP] 10 11 [/SUP], Leila C Sahni[SUP] 10 11 [/SUP], Janet A Englund[SUP] 12 [/SUP], Eileen J Klein[SUP] 12 [/SUP], Constance E Ogokeh[SUP] 1 [/SUP], Angela P Campbell[SUP] 1 [/SUP], Manish M Patel[SUP] 1 [/SUP], New Vaccine Surveillance Network
Affiliations
Abstract
Studies have shown egg-adaptive mutations in influenza vaccine strains that might have impaired protection against circulating A(H3N2) influenza viruses during the 2016-17 and 2017-18 seasons. We employed the test-negative design and multivariable models to assess vaccine effectiveness against influenza-associated hospitalization and emergency department visits among children <18 years during the 2016-17 and 2017-18 seasons. Effectiveness was 71% (95% CI:59%-79%), 46% (95% CI:35%-55%), and 45% (95% CI:33%-55%) against A(H1N1)pdm09, A(H3N2), and B viruses respectively, across both seasons. During high-severity seasons with concerns for vaccine mismatch, vaccination offered substantial protection against severe influenza outcomes requiring hospitalization or emergency department visits among children.
Keywords: Influenza; children; test negative design; vaccination.
. 2021 Dec 24;jiab624.
doi: 10.1093/infdis/jiab624. Online ahead of print.
Vaccine Effectiveness against Influenza Hospitalization and Emergency Department Visits in Two A(H3N2) Dominant Influenza Seasons among Children <18 Years Old, New Vaccine Surveillance Network 2016-17 and 2017-18
Sara S Kim[SUP] 1 [/SUP], Eric A Naioti[SUP] 1 2 [/SUP], Natasha B Halasa[SUP] 3 [/SUP], Laura S Stewart[SUP] 3 [/SUP], John V Williams[SUP] 4 [/SUP], Marian G Michaels[SUP] 4 [/SUP], Rangaraj Selvarangan[SUP] 5 6 [/SUP], Christopher J Harrison[SUP] 5 [/SUP], Mary A Staat[SUP] 7 [/SUP], Elizabeth P Schlaudecker[SUP] 7 [/SUP], Geoffrey A Weinberg[SUP] 8 [/SUP], Peter G Szilagyi[SUP] 8 9 [/SUP], Julie A Boom[SUP] 10 11 [/SUP], Leila C Sahni[SUP] 10 11 [/SUP], Janet A Englund[SUP] 12 [/SUP], Eileen J Klein[SUP] 12 [/SUP], Constance E Ogokeh[SUP] 1 [/SUP], Angela P Campbell[SUP] 1 [/SUP], Manish M Patel[SUP] 1 [/SUP], New Vaccine Surveillance Network
Affiliations
- PMID: 34951451
- DOI: 10.1093/infdis/jiab624
Abstract
Studies have shown egg-adaptive mutations in influenza vaccine strains that might have impaired protection against circulating A(H3N2) influenza viruses during the 2016-17 and 2017-18 seasons. We employed the test-negative design and multivariable models to assess vaccine effectiveness against influenza-associated hospitalization and emergency department visits among children <18 years during the 2016-17 and 2017-18 seasons. Effectiveness was 71% (95% CI:59%-79%), 46% (95% CI:35%-55%), and 45% (95% CI:33%-55%) against A(H1N1)pdm09, A(H3N2), and B viruses respectively, across both seasons. During high-severity seasons with concerns for vaccine mismatch, vaccination offered substantial protection against severe influenza outcomes requiring hospitalization or emergency department visits among children.
Keywords: Influenza; children; test negative design; vaccination.