tetano
Editor, Senior Moderator
J Infect Dis
. 2024 Feb 29:jiae036.
doi: 10.1093/infdis/jiae036. Online ahead of print. Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Benedikt Strunz[SUP] 1 [/SUP], Christopher Maucourant[SUP] 1 [/SUP], Adi Mehta[SUP] 2 [/SUP], Hui Wan[SUP] 3 [/SUP], Likun Du[SUP] 3 [/SUP], Dan Sun[SUP] 1 [/SUP], Puran Chen[SUP] 1 [/SUP], Anna Nordlander[SUP] 4 [/SUP], Yu Gao[SUP] 1 [/SUP], Martin Cornillet[SUP] 1 [/SUP], Jonna Bister[SUP] 1 [/SUP], Egle Kvedaraite[SUP] 1 5 [/SUP], Wanda Christ[SUP] 1 [/SUP], Jonas Klingström[SUP] 1 [/SUP], Daniel Geanon[SUP] 1 [/SUP], Åsa Parke[SUP] 6 7 [/SUP], Anna Ekwall-Larson[SUP] 8 [/SUP], Laura Rivino[SUP] 9 10 [/SUP], Paul A MacAry[SUP] 11 [/SUP], Soo Aleman[SUP] 7 12 [/SUP], Marcus Buggert[SUP] 1 [/SUP], Hans-Gustaf Ljunggren[SUP] 1 [/SUP], Qiang Pan-Hammarström[SUP] 3 [/SUP], Fridtjof Lund-Johansen[SUP] 2 [/SUP], Kristoffer Strålin[SUP] 6 7 [/SUP], Niklas K Björkström[SUP] 1 [/SUP]; Karolinska KI/K COVID-19 Study Group
Collaborators, Affiliations
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).
Methods: This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.
Results: aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.
Conclusions: Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.
Keywords: COVID-19; autoantibodies; immunity; interferon.
. 2024 Feb 29:jiae036.
doi: 10.1093/infdis/jiae036. Online ahead of print. Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Benedikt Strunz[SUP] 1 [/SUP], Christopher Maucourant[SUP] 1 [/SUP], Adi Mehta[SUP] 2 [/SUP], Hui Wan[SUP] 3 [/SUP], Likun Du[SUP] 3 [/SUP], Dan Sun[SUP] 1 [/SUP], Puran Chen[SUP] 1 [/SUP], Anna Nordlander[SUP] 4 [/SUP], Yu Gao[SUP] 1 [/SUP], Martin Cornillet[SUP] 1 [/SUP], Jonna Bister[SUP] 1 [/SUP], Egle Kvedaraite[SUP] 1 5 [/SUP], Wanda Christ[SUP] 1 [/SUP], Jonas Klingström[SUP] 1 [/SUP], Daniel Geanon[SUP] 1 [/SUP], Åsa Parke[SUP] 6 7 [/SUP], Anna Ekwall-Larson[SUP] 8 [/SUP], Laura Rivino[SUP] 9 10 [/SUP], Paul A MacAry[SUP] 11 [/SUP], Soo Aleman[SUP] 7 12 [/SUP], Marcus Buggert[SUP] 1 [/SUP], Hans-Gustaf Ljunggren[SUP] 1 [/SUP], Qiang Pan-Hammarström[SUP] 3 [/SUP], Fridtjof Lund-Johansen[SUP] 2 [/SUP], Kristoffer Strålin[SUP] 6 7 [/SUP], Niklas K Björkström[SUP] 1 [/SUP]; Karolinska KI/K COVID-19 Study Group
Collaborators, Affiliations
- PMID: 38421006
- DOI: 10.1093/infdis/jiae036
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).
Methods: This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.
Results: aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.
Conclusions: Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.
Keywords: COVID-19; autoantibodies; immunity; interferon.