tetano
Editor, Senior Moderator
J Infect Dis
. 2020 Aug 3;jiaa486.
doi: 10.1093/infdis/jiaa486. Online ahead of print.
Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques
Bon-Sang Koo[SUP] 1 [/SUP], Hanseul Oh[SUP] 1 [/SUP], Green Kim[SUP] 1 [/SUP], Eun-Ha Hwang[SUP] 1 [/SUP], Hoyin Jung[SUP] 1 [/SUP], Youngjeon Lee[SUP] 1 [/SUP], Philyong Kang[SUP] 2 [/SUP], Jae-Hak Park[SUP] 3 [/SUP], Choong-Min Ryu[SUP] 4 [/SUP], Jung Joo Hong[SUP] 1 [/SUP]
Affiliations
Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titres of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
Keywords: Lymphopenia; Macaques; Pneumonia; SARS-CoV-2.
. 2020 Aug 3;jiaa486.
doi: 10.1093/infdis/jiaa486. Online ahead of print.
Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques
Bon-Sang Koo[SUP] 1 [/SUP], Hanseul Oh[SUP] 1 [/SUP], Green Kim[SUP] 1 [/SUP], Eun-Ha Hwang[SUP] 1 [/SUP], Hoyin Jung[SUP] 1 [/SUP], Youngjeon Lee[SUP] 1 [/SUP], Philyong Kang[SUP] 2 [/SUP], Jae-Hak Park[SUP] 3 [/SUP], Choong-Min Ryu[SUP] 4 [/SUP], Jung Joo Hong[SUP] 1 [/SUP]
Affiliations
- PMID: 32745172
- DOI: 10.1093/infdis/jiaa486
Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titres of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
Keywords: Lymphopenia; Macaques; Pneumonia; SARS-CoV-2.