tetano
Editor, Senior Moderator
J Infect Dis. 2020 May 7. pii: jiaa252. doi: 10.1093/infdis/jiaa252. [Epub ahead of print]
T cell subset counts in peripheral blood can be used as discriminatory biomarkers for diagnosis and severity prediction of COVID-19.
Jiang M[SUP]1[/SUP], Guo Y[SUP]1[/SUP], Luo Q[SUP]1[/SUP], Huang Z[SUP]1[/SUP], Zhao R[SUP]1[/SUP], Liu S[SUP]1[/SUP], Le A[SUP]2[/SUP], Li J[SUP]1[/SUP], Wan L[SUP]1[/SUP].
Author information
Abstract
This study evaluated the significance of lymphocyte subsets detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+T, CD4+T, CD8+T cells and NK cells were significantly decreased in COVID-19 patients. COVID-19 patients had a relatively slight decrease in CD4+T cells but a severe decrease of CD8+T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T cell subset counts were related to the severity and prognosis of COVID-19. The counts of CD8+T and CD4+T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
KEYWORDS:
SARS-CoV2; diagnosis; lymphocyte subsets; prognosis
PMID:32379887DOI:10.1093/infdis/jiaa252
T cell subset counts in peripheral blood can be used as discriminatory biomarkers for diagnosis and severity prediction of COVID-19.
Jiang M[SUP]1[/SUP], Guo Y[SUP]1[/SUP], Luo Q[SUP]1[/SUP], Huang Z[SUP]1[/SUP], Zhao R[SUP]1[/SUP], Liu S[SUP]1[/SUP], Le A[SUP]2[/SUP], Li J[SUP]1[/SUP], Wan L[SUP]1[/SUP].
Author information
Abstract
This study evaluated the significance of lymphocyte subsets detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+T, CD4+T, CD8+T cells and NK cells were significantly decreased in COVID-19 patients. COVID-19 patients had a relatively slight decrease in CD4+T cells but a severe decrease of CD8+T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T cell subset counts were related to the severity and prognosis of COVID-19. The counts of CD8+T and CD4+T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
KEYWORDS:
SARS-CoV2; diagnosis; lymphocyte subsets; prognosis
PMID:32379887DOI:10.1093/infdis/jiaa252